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Human PARP1 Knockdown Cell Line-HeLa

Cat.No.
CSC-RK0018
Abbr
HeLa-HuPARP1 Knockdown
Alias
PARP1,PPOL,ADPRT,ADPRT1,PARP-1,ADPRT 1,pADPRT-1,
Growth Properties
Adherent
Host Cell
HeLa
Morphology
Epithelial
Shipping
Dry ice
Species
Human
Background
This gene encodes a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes.

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