Human PARP1 Knockdown Cell Line - Glioma

Name: Human PARP1 Knockdown Cell Line - Glioma
SKU: CSC-RK0213
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CSC-RK0213

Host Cell : Glioma Validation : Real-Time RCR

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Cell Line Information

Safety and Packaging

Gene Information

Cat. No.	CSC-RK0213
Description	This cell line is engineered to stably express shRNA targeting human PARP1.
Target Gene	PARP1
Host Cell	Glioma
Host Cell Species	Homo sapiens (Human)
Applications	(1) Studying gene functions (2) Studying gene interactions and signaling pathways (3) Target validation and drug discovery (4) Designing diseases models
Size	>1 × 10⁶ cells / vial
Stability	Validated for at least 10 passages
Validation	Real-Time RCR
Storage	Liquid nitrogen
Shipping	Dry ice

Mycoplasma	Negative
Format	One frozen vial containing millions of cells
Storage	Liquid nitrogen
Safety Considerations	The following safety precautions should be observed. 1. Use pipette aids to prevent ingestion and keep aerosols down to a minimum. 2. No eating, drinking or smoking while handling the stable line. 3. Wash hands after handling the stable line and before leaving the lab. 4. Decontaminate work surface with disinfectant or 70% ethanol before and after working with stable cells. 5. All waste should be considered hazardous. 6. Dispose of all liquid waste after each experiment and treat with bleach.
Ship	Dry ice

Gene Name	PARP1 poly (ADP-ribose) polymerase 1 [ Homo sapiens ]
Gene Symbol	PARP1
Synonyms	PARP; PPOL; ADPRT; ARTD1; ADPRT1; PARP-1; ADPRT 1; pADPRT-1
Gene Description	poly (ADP-ribose) polymerase family, member 1
GeneID	142
Uni ProtID	P09874
mRNA Refseq	NM_001618.3
Protein Refseq	NP_001609.2
Chromosome Location	1q41-q42
Function	DNA binding; NAD binding; NAD+ ADP-ribosyltransferase activity; NAD+ ADP-ribosyltransferase activity; protein N-terminus binding; protein binding; transcription factor binding; zinc ion binding;
Pathway	BER complex, organism-specific biosystem; BER complex, conserved biosystem; Base excision repair, organism-specific biosystem; Base excision repair, conserved biosystem; Caspase cascade in apoptosis, organism-specific biosystem; Downregulation of SMAD2/3:SMAD4 transcriptional activity, organism-specific biosystem; FAS pathway and Stress induction of HSP regulation, organism-specific biosystem;
MIM	173870

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