Human MERTK Stable Cell Line - HEK293

Atherosclerosis is a complex vascular disease characterized by the accumulation of lipids and immune cells, leading to plaque formation in arterial walls. Research has identified the MERTK gene, which encodes a ligand-activated transmembrane tyrosine kinase, as a potential contributor to the disease process. Researchers investigated the influence of strain differences in MERTK on plaque formation by creating a congenic mouse line. This study revealed that mice with the DBA/2J allele of MERTK developed significantly larger atherosclerotic plaques compared to control mice. The findings highlighted that reduced expression of MERTK in macrophages from these mice correlated with impaired phagocytosis of apoptotic cells, shedding light on the role of MERTK in atherogenesis.

Figure 1. The researchers employed HEK293T cells to investigate MERTK expression and its impact on phagocytosis, aiming to understand its role in atherosclerosis. (Kayashima Y, et al., 2017)

Creative Biogene's Human MERTK Stable Cell Line - HEK293 is designed for researchers seeking to explore MERTK's functional role in various cellular processes, including apoptosis and immune responses. This cell line offers a reliable platform for studying the relationship between MERTK levels and phagocytic activity, facilitating the understanding of MERTK's influence on atherosclerosis and other diseases.