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Human ADRB2-tGFP Stable Cell Line-CHO

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Cat.No.
CSC-RG0025
Background
This gene encodes beta-2-adrenergic receptor which is a member of the G protein-coupled receptor superfamily. The adrenergic receptors are a class of G protein-coupled receptors that are targets of the catecholamines, especially noradrenaline (norepinephrine) andadrenaline (epinephrine). Although dopamine is a catecholamine, its receptors are in a different category. This receptor is directly associated with one of its ultimate effectors, the class C L-type calcium channel Ca(V)1.2. This receptor-channel complex also contains a G protein, an adenylyl cyclase, cAMP-dependent kinase, and the counterbalancing phosphatase, PP2A. Many cells possess these receptors, and the binding of an agonist will generally cause a sympathetic response (i.e. the fight-or-flight response). Different polymorphic forms, point mutations, and/or downregulation of this gene are associated with nocturnal asthma, obesity and type 2 diabetes.
Growth Properties
Adherent
Morphology
Epithelial-like
Host Cell
CHO-K1
Ship
Dry ice
Gene Information
Official Symbol
ADRB2
Synonyms
ADRB2; ADRB2R; ADRBR; B2AR; BAR; BETA2AR; adrenoceptor beta 2, surface; beta-2 adrenergic receptor; beta-2 adrenoceptor; beta-2 adrenoreceptor; catecholamine receptor; adrenergic, beta-2-, receptor, surface
Gene ID
MIM
UniProt ID
P07550
Chromosome Location
5q31-q32
Pathway
Adrenoceptors; Amine ligand-binding receptors; Arf6 signaling events; Calcium signaling pathway; Class A/1 (Rhodopsin-like receptors); Endocytosis; G alpha (s) signalling events;
Function
adenylate cyclase binding; beta2-adrenergic receptor activity; dopamine binding; drug binding; epinephrine binding; ionotropic glutamate receptor binding; norepinephrine binding; potassium channel regulator activity; protein binding; protein homodimerization activity

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