Tel: 1-631-626-9181 (USA)   44-207-097-1828 (Europe)
  Email:

USP14 Knockout Cell Line-HeLa

Cat.No.
CSC-RT0138
Description
HeLa-USP14 (-/-) is a stable cell line with a homozygous knockout of human USP14
Host Cell
HeLa
Background
This gene encodes a member of the ubiquitin-specific processing (UBP) family of proteases that is a deubiquitinating enzyme (DUB) with His and Cys domains. This protein is located in the cytoplasm and cleaves the ubiquitin moiety from ubiquitin-fused precursors and ubiquitinylated proteins. Mice with a mutation that results in reduced expression of the ortholog of this protein are retarded for growth, develop severe tremors by 2 to 3 weeks of age followed by hindlimb paralysis and death by 6 to 10 weeks of age. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

Quick Inquiry

   Please input "biogene" as verification code.