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Human MRGPRX2 Stable Cell Line-HEK293

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Cat.No.
CSC-RG0895
Background
This receptor belongs to a family of 4 sensory neuron-specific G-protein coupled receptors that are expressed in small diameter primary sensory neurons and in several other tissues. MrgX2 is a Gi- and Gq-coupled receptor which is potently activated by cortistatin-14. Because of its expression in sensory neurons and because these sensory neurons transmit pain sensation, this receptor is of interest as a therapeutic targets for pain medications. This cell line, expressed in HEK293 cells with no other exogenous G proteins, displays a robust calcium response and will be useful as a drug discovery reagent.
Growth Properties
Adherent
Morphology
Epithelial
Host Cell
HEK293
Stability
At least 8 passages
Ship
Dry ice
Gene Information
Official Symbol
MRGPRX2
Synonyms
MRGPRX2; MAS-related GPR, member X2; mas-related G-protein coupled receptor member X2; MRGX2; G protein-coupled receptor MRGX2;
Gene ID
MIM
UniProt ID
Q96LB1
Chromosome Location
11p15.1
Function
G-protein coupled receptor activity; neuropeptide binding; receptor activity; signal transducer activity;

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