Human MRGPRX2 Stable Cell Line-CHO-K1

Name: Human MRGPRX2 Stable Cell Line-CHO-K1
SKU: CSC-RG1664
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CSC-RG1664

Host Cell : CHO-K1 Size : >1x10⁶ frozen cells/vial

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Cell Line Information

Cell Culture Information

Safety and Packaging

Gene Information

Cat. No.	CSC-RG1664
Background	Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptorfunction and/or development, including the sensation or modulation of pain. Cortistatin-14 seems to be a highpotency ligand at this receptor. Cortistatin has several biological functions including roles in sleep regulationlocomotor activity, and cortical function. In receptor-expressing cells, cortistatin-stimulated increases inintracellular Ca(2+) but had no effect on basal or forskolin-stimulated cAMP levels, suggesting that thisreceptor is G(q)-coupled.
Target Gene	MRGPRX2
Gene Species	Homo sapiens (Human)
Host Cell	CHO-K1
Host Cell Species	Cricetulus griseus (Chinese hamster)
Source	CHO-K1
Applications	1. Gene expression studies 2. Signaling pathway research 3. Drug screening and toxicology 4. Research on the mechanisms of GPCR-related diseases
Size	>1x10⁶ frozen cells/vial
Stability	Validated for at least 10 passages
Quality Control	Negative for bacteria, yeast, fungi and mycoplasma.
Storage	Liquid nitrogen
Shipping	Dry Ice

Revival

Rapidly thaw cells in a 37°C water bath. Transfer contents into a tube containing pre-warmed media. Centrifuge cells and seed into a 25 cm2 flask containing pre-warmed media.

Mycoplasma	Negative
Format	One frozen vial containing millions of cells
Storage	Liquid nitrogen
Safety Considerations	The following safety precautions should be observed. 1. Use pipette aids to prevent ingestion and keep aerosols down to a minimum. 2. No eating, drinking or smoking while handling the stable line. 3. Wash hands after handling the stable line and before leaving the lab. 4. Decontaminate work surface with disinfectant or 70% ethanol before and after working with stable cells. 5. All waste should be considered hazardous. 6. Dispose of all liquid waste after each experiment and treat with bleach.
Ship	Dry ice

Gene Name	MRGPRX2 MAS-related GPR, member X2 [ Homo sapiens ]
Gene Symbol	MRGPRX2
Synonyms	MRGPRX2; MAS-related GPR, member X2; mas-related G-protein coupled receptor member X2; MRGX2; G protein-coupled receptor MRGX2;
GeneID	117194
Uni ProtID	Q96LB1
mRNA Refseq	BC063450
Chromosome Location	11p15.1
Function	G-protein coupled receptor activity; neuropeptide binding; receptor activity; signal transducer activity;
MIM	607228

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