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Rituximab Stable Cell Line - CHO-K1

For research use only. Not intended for any clinical use.

Cat. No. :   CSC-BS0001

Host Cell :   CHO-K1 Size :   >1x106 frozen cells/vial

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Cell Line Information

Cell Culture Information

Safety and Packaging

Cat. No. CSC-BS0001
Description This cell line is engineered to stably produce Rituximab which is a monoclonal antibody against human MS4A1/CD20.
Target Gene Rituximab
Host Cell CHO-K1
Host Cell Species Cricetulus griseus (Chinese hamster)
Applications

1. Biosimilar Development

2. Large-Scale Biomanufacturing

3. Preclinical Research

4. Drug Development and Testing

Size >1x106 frozen cells/vial
Stability Validated for at least 10 passages
Quality Control Negative for bacteria, yeast, fungi and mycoplasma.
Growth Conditions 37° C, 5% CO2
Storage Liquid nitrogen
Shipping Dry ice
Revival Rapidly thaw cells in a 37°C water bath. Transfer contents into a tube containing pre-warmed media. Centrifuge cells and seed into a 25 cm2 flask containing pre-warmed media.
Mycoplasma Negative
Format One frozen vial containing millions of cells
Storage Liquid nitrogen
Safety Considerations The following safety precautions should be observed.
1. Use pipette aids to prevent ingestion and keep aerosols down to a minimum.
2. No eating, drinking or smoking while handling the stable line.
3. Wash hands after handling the stable line and before leaving the lab.
4. Decontaminate work surface with disinfectant or 70% ethanol before and after working with stable cells.
5. All waste should be considered hazardous.
6. Dispose of all liquid waste after each experiment and treat with bleach.
Ship Dry ice
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Q & A

Customer Reviews

Customer Q&As
What is Rituximab?

A: Rituximab is a monoclonal antibody commonly used to treat various types of cancer and autoimmune diseases.

What is the mechanism of action of Rituximab?

A: Rituximab works by binding to the CD20 protein on the surface of cancerous B cells. This binding sets off a chain of events that culminates in the destruction of these cancer cells through a process called antibody-dependent cellular cytotoxicity (ADCC).

What is rituximab treatment for?

A: Rituximab injection is used alone or with other medicines to treat a type of cancer called non-Hodgkin's lymphoma (NHL). It is also used in combination with other anticancer drugs to treat mature B-cell non-Hodgkin's lymphoma (NHL) and mature B-cell acute leukemia (B-AL).

What is the success rate of rituximab?

A: Rituximab, used as a single agent, is very effective in several types of indolent lymphoma, with response rates (RR) of 45% to 60% even in treated patients,1-3 and in more In the aggressive form of NHL, the response rate (RR) is approximately 30%.

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Customer Reviews
Maintain consistency across batches

These Rituximab Stable Cell Lines are capable of growing under very specific conditions, which can be easily replicated to maintain consistency across batches.

United States

Ideal platform for commercial production

The CHO-K1 cells can produce high levels of rituximab, making it an ideal platform for commercial production.

United States

Effective

Great buy! The Rituximab Stable Cell Line remains effective in targeting the CD20 protein across multiple generations.

United States

Can large-scale production of rituximab

The use of these cell lines has allowed for the large-scale production of rituximab. I recommend it.

Germany

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