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Cat.No. : CSC-BS0004 Host Cell: CHO-K1
| Cat. No. | CSC-BS0004 |
| Description | This cell line is engineered to stably produce Nivolumab which is a monoclonal antibody against human PDCD1/PD1. |
| Biosimilar | Nivolumab |
| Host Cell | CHO-K1 |
| Host Cell Species | Cricetulus griseus (Chinese hamster) |
| Stability | Validated for at least 10 passages |
| Application | 1. Biosimilar Development 2. Large-Scale Biomanufacturing 3. Preclinical Research 4. Drug Development and Testing |
| Growth Conditions | 37° C, 5% CO2 |
| Quality Control | Negative for bacteria, yeast, fungi and mycoplasma. |
| Shipping | Dry ice |
| Storage | Liquid nitrogen |
| Mycoplasma | Negative |
| Format | One frozen vial containing millions of cells |
| Storage | Liquid nitrogen |
| Safety Considerations |
The following safety precautions should be observed. 1. Use pipette aids to prevent ingestion and keep aerosols down to a minimum. 2. No eating, drinking or smoking while handling the stable line. 3. Wash hands after handling the stable line and before leaving the lab. 4. Decontaminate work surface with disinfectant or 70% ethanol before and after working with stable cells. 5. All waste should be considered hazardous. 6. Dispose of all liquid waste after each experiment and treat with bleach. |
| Ship | Dry ice |
A: Nivolumab is a type of cancer treatment drug called immunotherapy. It's a treatment for a number of different types of cancer.
A: Nivolumab works by blocking the interaction between PD-1 and its ligands, leading to the activation of T-cells and the destruction of cancer cells.
A: Nivolumab is used alone or with other drugs to treat certain types of esophageal cancer, stomach cancer, colorectal cancer, gastroesophageal junction cancer, non-small cell lung cancer, renal cell carcinoma, melanoma, hepatocellular carcinoma, Squamous cell carcinoma of the head and neck and urothelial carcinoma.
A: Developing a Nivolumab stable cell line requires genetic engineering techniques that insert the PD-1 receptor sequence into the CHO-K1 cell genome. The engineered cells are then selected, screened, and cultured to obtain a pure, robust cell population that secrete Nivolumab.
A: CHO-K1 cells are a popular choice for antibody production due to their ability to grow and divide rapidly, their capacity for high-density culture, and their adaptability to a variety of culture conditions.
If your question is not addressed through these resources, you can fill out the online form below and we will answer your question as soon as possible.
Great buy! The use of stable cell lines reduces the time and cost of Nivolumab development, as well as ensuring consistency in the quality of the Nivolumab.
United States
05/12/2021
The Nivolumab stable cell lines can produce large quantities of Nivolumab consistently over an extended period. I recommend it.
United Kingdom
08/15/2021
Great! This Nivolumab Stable Cell Line is an invaluable tool in my drug development.
United States
10/09/2021
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