Human NECTIN4 Knockout Cell Line-HEK293T

NECTIN4, also known as nectin cell adhesion molecule 4, is a gene encoding a member of the nectin family of cell adhesion molecules. NECTIN4 is primarily expressed in epithelial tissues, including the skin, lungs, and bladder, and is involved in cell-cell adhesion, migration, and proliferation. Nectin-4 protein is initially synthesized as a precursor and undergoes glycosylation and other post-translational modifications to become the mature form. The mature nectin-4 protein is then localized to the cell membrane, where it interacts with other cellular proteins to mediate its actions. One of its key roles is to promote the formation of homo- and heterodimers with other nectin family members, such as NECTIN1, NECTIN2, and NECTIN3, to form functional adhesion complexes. These complexes are essential for the formation of a tight barrier between epithelial cells and play a role in signaling pathways that regulate cell behavior. In terms of disease, abnormal expression of NECTIN4 has been associated with multiple types of cancer, including breast, ovarian, and bladder cancers. Due to its restricted expression in normal tissues but prominent in certain cancers, NECTIN4 has emerged as a potential target for cancer therapy. In addition to its role in cancer, NECTIN4 has been implicated in a genetic disorder called ectodermal dysplasia-syndactyly syndrome type 1 (EDSS1), which is characterized by abnormalities of the skin, hair, teeth, and nails, indicating the importance of the normal function of NECTIN4 in normal human development.