Panoply™ Human SLC2A1 Knockdown Stable Cell Line

Name: Panoply™ Human SLC2A1 Knockdown Stable Cell Line
SKU: CSC-DC014478

Cat.No. : CSC-DC014478

Host Cell: HEK293 (Hela and other cell types are also available) Validation: Real-Time RCR

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Cat. No.	CSC-DC014478
Description	Creative Biogene's Knockdown Cell Lines are target specific shRNA lentivirus transduced cells. The percent knockdown levels range from 75-99% depending on the gene, as evaluated by Real-Time RCR. Cells are rigorously qualified and mycoplasma free.
Gene	SLC2A1
Host Cell	HEK293 (Hela and other cell types are also available)
Host Cell Species	Homo sapiens (Human)
Stability	Validated for at least 10 passages
Application	(1) Studying gene functions (2) Studying gene interactions and signaling pathways (3) Target validation and drug discovery (4) Designing diseases models
Quality Control	Negative for bacteria, yeast, fungi and mycoplasma.
Size Form	>1 × 10^6 cells / vial
Shipping	Dry Ice
Storage	Liquid Nitrogen

Mycoplasma	Negative
Format	One frozen vial containing millions of cells
Storage	Liquid nitrogen
Safety Considerations	The following safety precautions should be observed. 1. Use pipette aids to prevent ingestion and keep aerosols down to a minimum. 2. No eating, drinking or smoking while handling the stable line. 3. Wash hands after handling the stable line and before leaving the lab. 4. Decontaminate work surface with disinfectant or 70% ethanol before and after working with stable cells. 5. All waste should be considered hazardous. 6. Dispose of all liquid waste after each experiment and treat with bleach.
Ship	Dry ice

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What is SLC2A1？

A: Solute carrier family 2 (facilitated glucose transporter) member 1. is the major glucose transporter protein in the blood-brain barrier, facilitating the transport of glucose to the brain

What is the role of SLC2A1?

A: SLC2A1 This gene encodes a GLUTI consisting of 492 amino acids, and its structural model contains 12 transmembrane fragments that are present in the capillary endothelial cell membranes of brain tissue, responsible for transporting glucose across the blood-brain barrier, and is the major glucose transporter protein of the mammalian blood-brain barrier.

What is the relationship between glucose transporter 1 deficiency syndrome and SLC2A1?

A: Glucose transporter 1 deficiency syndrome is caused by mutations in the SLC2A1 gene, localized on chromosome 1, and expresses a protein that has a role in transporting glucose across the blood-brain barrier and red blood cell membranes.

What happens in the body as a result of mutations in the SLC2A1 gene?

A: Mutations in the SLC2A1 gene result in reduced expression or partial loss of function of glucose transporter 1, and glucose cannot effectively cross the blood-brain barrier

Why is glucose so important to the brain?

A: If glucose fails to cross the blood-brain barrier, it leads to a lack of energy supply to brain tissue and produces a range of neurological symptoms.

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