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HumanDRD3-tGFP Stable Cell Line-SHSY5Y

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Cat.No.
CSC-RG0037
Background
The gene encodes the D3 subtype of the Dopamine receptor. This subtype is a G-protein coupled receptor which stimulates adenylyl cyclase. Dopamine is one of the most important neurotransmitters and the expression of its receptors is well characterized in brain.
Dopamine receptors are involved in many neurological processes so their abnormal signalling is implicated in several neuropsychiatric disorders. DRD3 is found in the limbic areas of the brain, which usually are associated with cognitive, emotional, and endocrine functions. DRD3 is a target for drugs which treat schizophrenia, drug addiction, and Parkinson"s disease.
Growth Properties
Mixed, adherent and suspension
Morphology
Epithelial
Host Cell
SHSY5Y
Ship
Dry ice
Gene Information
Official Symbol
DRD3
Synonyms
DRD3; dopamine receptor D3; D dopamine receptor; essential tremor 1; dopamine D3 receptor; D3DR; ETM1; FET1; MGC149204; MGC149205;
Gene ID
MIM
UniProt ID
P35462
Chromosome Location
3q13.3
Pathway
Amine ligand-binding receptors, organism-specific biosystem; Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; Dopamine receptors, organism-specific biosystem; Dopaminergic synapse, organism-specific biosystem; Dopaminergic synapse, conserved biosystem; G alpha (i) signalling events, organism-specific biosystem; GPCR downstream signaling, organism-specific biosystem;
Function
G-protein coupled receptor activity; dopamine binding; dopamine receptor activity, coupled via Gi/Go; dopamine receptor activity, coupled via Gi/Go; drug binding; drug binding; protein binding; protein domain specific binding; receptor activity; signal transducer activity;

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