Human SDC1 Knockout Cell Line-HeLa

SDC1 or Syndecan-1 is a transmembrane heparan sulfate proteoglycan that plays a key role in cell communication, signaling pathways, and cell-extracellular matrix interactions. Syndecan-1 is primarily expressed on the surface of epithelial cells, particularly in tissues such as the skin, breast, and gastrointestinal tract, as well as in certain hematopoietic cells. One of the main functions of SDC1 is its involvement in cell adhesion. As a coreceptor, it binds to a variety of ligands, including growth factors, chemokines, and extracellular matrix components such as fibronectin and collagen. Through these interactions, SDC1 mediates processes such as cell proliferation, migration, and differentiation, significantly affecting tissue morphogenesis and repair. In addition to its biological functions in normal physiology, SDC1 has been extensively studied in pathological contexts. Its altered expression has been associated with a variety of diseases, including various types of cancer, where its expression levels are often correlated with tumor progression, metastasis, and patient prognosis. For example, elevated levels of SDC1 are commonly observed in multiple myeloma, which not only provides a diagnostic biomarker but also a potential therapeutic target. Targeting SDC1 via antibodies or small molecules has shown promise in preclinical studies, aiming to disrupt its interaction with key growth factors or modulate its shedding from the cell surface.