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Cat.No. : CSC-RG0047 Host Cell: CHO
| Cat. No. | CSC-RG0047 |
| Background | This gene encodes the D2 subtype of the dopamine receptor. This G-protein coupled receptor inhibits adenylyl cyclase activity. A missense mutation in this gene causes myoclonus dystonia; other mutations have been associated with schizophrenia. Alternative splicing of this gene results in two transcript variants encoding different isoforms. A third variant has been described, but it has not been determined whether this form is normal or due to aberrant splicing. |
| Gene | DRD2 |
| Gene Species | Homo sapiens (Human) |
| Alias | D2R, D2DR, DRD2 |
| Host Cell | CHO |
| Species | Cricetulus griseus (Chinese hamster) |
| Morphology | Epithelial-like |
| Stability | Validated for at least 10 passages |
| Application | 1. Gene expression studies 2. Signaling pathway research 3. Drug screening and toxicology 4. Research on the mechanisms of GPCR-related diseases |
| Quality Control | Negative for bacteria, yeast, fungi and mycoplasma. |
| Shipping | Dry ice |
| Storage | Liquid nitrogen |
| Revival | Rapidly thaw cells in a 37°C water bath. Transfer contents into a tube containing pre-warmed media. Centrifuge cells and seed into a 25 cm2 flask containing pre-warmed media. |
| Growth Properties | Adherent |
| Mycoplasma | Negative |
| Format | One frozen vial containing millions of cells |
| Storage | Liquid nitrogen |
| Safety Considerations |
The following safety precautions should be observed. 1. Use pipette aids to prevent ingestion and keep aerosols down to a minimum. 2. No eating, drinking or smoking while handling the stable line. 3. Wash hands after handling the stable line and before leaving the lab. 4. Decontaminate work surface with disinfectant or 70% ethanol before and after working with stable cells. 5. All waste should be considered hazardous. 6. Dispose of all liquid waste after each experiment and treat with bleach. |
| Ship | Dry ice |
A: Future research with the Human DRD2-SNAP Stable Cell Line-CHO may involve the development of advanced imaging techniques, the integration of CRISPR/Cas9 for precise genetic editing, and the use of high-throughput screening methods. These advancements could lead to a deeper understanding of DRD2's role in brain function and disease, the discovery of novel therapeutic targets, and the optimization of existing treatments.
A: The Human DRD2-SNAP Stable Cell Line-CHO can be used to study individual patient-derived cell lines, allowing for the investigation of how genetic variations in DRD2 affect drug responses. This personalized approach can lead to the development of tailored treatments for patients with DRD2-related conditions, improving therapeutic outcomes and reducing adverse effects.
A: The Human DRD2-SNAP Stable Cell Line-CHO enables researchers to study the downstream signaling cascades activated by DRD2 in response to dopamine or other ligands. By using this cell line, scientists can investigate the intracellular signaling networks, protein-protein interactions, and cellular responses that are modulated by DRD2 activation.
A: Maintaining the stability of the DRD2-SNAP fusion protein over time can be challenging due to potential genetic drift or selection pressure. Researchers address this by using appropriate selection markers, regular monitoring of the fusion protein expression, and periodic recloning to ensure the cell line retains its original characteristics.
A: Yes, the Human DRD2-SNAP Stable Cell Line-CHO is a powerful tool for drug screening and pharmacological studies. By observing how drugs interact with the DRD2 receptor, researchers can evaluate their efficacy, selectivity, and potential side effects. This information is critical for the development of new therapeutics targeting DRD2-related disorders.
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