2′-O-methyltransferase

Name: 2′-O-methyltransferase
SKU: RSNK-025

For research use only. Not intended for any clinical use.

Cat.No.

RSNK-025

Description

2′-O-Methyltransferase is a methyltransferase which utilizes S-adenosylmethionine (SAM) as a methyl donor to add a methyl group at the 2′-O position of the first nucleotide adjacent to the cap structure at the 5′ end of the RNA. This enzyme is used to prepare cap1 capped RNA from a cap0-RNA.

Concentration

50 U/μl

Size/Form

7.5 KU, 50 KU

Source

An E. coli strain that carries the Vaccinia 2′-O-methyltransferase gene.

Storage

Store at -20 °C

Publications

Q & A

Customer Reviews

Customer Q&As

What is 2′-O-methyltransferase?

A: 2′-O-methyltransferase is an enzyme responsible for mRNAs ribose 2′-O-methylation in eukaryotic cells and many viruses. Methylation of viral RNAs is an important for their genome replication and evasion of innate recognition of viral RNAs by the cellular sensors of the target cell.

What is the role of 2′-O-methyltransferase in RNA?

A: 2'-O-methyltransferase is an enzyme responsible for the modification of RNA molecules. It adds a methyl group to the 2' oxygen atom of the ribose sugar in the RNA backbone. This methylation can enhance the stability of RNA molecules, protect them from degradation, affect their activity and localization in cells, and play a role in the immune evasion of certain viruses.

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