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5-Methoxy-UTP

For research use only. Not intended for any clinical use.
Cat.No.
RSNK-019
Description
5-Methoxy-UTP is a modified NTP for incorporation into messenger RNAs (mRNA) using T7 RNA Polymerase. The Incorporation of 5-Methoxy-UTP can reduce the mRNA immunogenicity.
Alias
5-Methoxyuridine-5’-Triphosphate
Applications
In vitro transcription
Molecular Formula
C10H17N2O16P3
Molecular Weight
514.1
Purity
≥90%
Size/Form
1 µmol, 5 µmol
Storage
Store at -20°C.

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Q & A

Customer Reviews

Customer Q&As
What is 5-Methoxy-UTP?

A: 5-Methoxy-UTP is a modified nucleotide that contains a methoxy group (-OCH3) at the 5' position of the uridine base. It is a substrate for RNA polymerases and can be incorporated into RNA molecules during transcription.

Can 5-Methody-UTP label RNA molecules?

A: Yes. 5-Methody-UTP can be used for labeling RNA molecules for visualization or detection purposes, as the methoxy group can be conjugated to fluorescent dyes or other labeling molecules.

What are the applications of 5-Methody-UTP in structure-function studies of RNA?

A: 5-Methoxy-UTP can be used for structural functional research of RNA, as it can generate modified RNA molecules with altered properties. For example, the incorporation of 5-methoxy-UTP can alter the tertiary structure of RNA, affect RNA protein interactions, or alter RNA stability.

What are the applications of 5-Methody-UTP in drug development?

A: 5-Methoxy-UTP has been shown to cross the blood-brain barrier more efficiently than other nucleoside analogs, making it a potential candidate for the treatment of neurological disorders.

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Customer Reviews
Worked Very Well

5-Methoxy-UTP can protect RNA from degradation by RNases compared to unmodified UTP. I recommend it.

United States

01/31/2022

Useful tool

This is particularly useful for experiments that require high RNA labeling efficiency, such as microarray analysis or RNA sequencing. I like it.

United States

08/05/2022

High Efficiency

Better reverse transcription - 5-MeOTTP can enhance reverse transcription efficiency when used as a substrate for cDNA synthesis. I have repurchased it multiple times.

United States

03/15/2023

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