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sepw2b

Official Full Name
selenoprotein W, 2b
Organism
Danio rerio
GeneID
378438
Background
This gene encodes a selenoprotein containing a selenocysteine (Sec) residue, which is encoded by the UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This protein belongs to the SelWTH family, which possesses a thioredoxin-like fold and a conserved CxxU (C is cysteine, U is Sec) motif, suggesting a redox function for this gene. Unlike in mammals, where this protein is highly expressed in skeletal muscle, heart and brain; it is expressed in sensory organs in zebrafish. Paralogs of this gene, sepw1 and sepw2a, are found on chromosomes 5 and 3, respectively. [provided by RefSeq, Jul 2017]
Synonyms
cb696; sepw2b; zgc:123142; zgc:152839; si:dz180g5.2;

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