OLR1

Official Full Name

oxidized low density lipoprotein receptor 1

Organism

Homo sapiens

Gene ID

4973

Background

This gene encodes a low density lipoprotein receptor that belongs to the C-type lectin superfamily. This gene is regulated through the cyclic AMP signaling pathway. The encoded protein binds, internalizes and degrades oxidized low-density lipoprotein. This protein may be involved in the regulation of Fas-induced apoptosis. This protein may play a role as a scavenger receptor. Mutations of this gene have been associated with atherosclerosis, risk of myocardial infarction, and may modify the risk of Alzheimer's disease. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Feb 2010]

Synonyms

LOX1; LOXIN; SLOX1; CLEC8A; SCARE1

Cat.No.	Product Name	Price
CSC-DC010841	Panoply™ Human OLR1 Knockdown Stable Cell Line	Inquiry
CSC-SC010841	Panoply™ Human OLR1 Over-expressing Stable Cell Line	Inquiry
CSC-RT0607	Human OLR1 Knockout Cell Line-HeLa	Inquiry
CLOE-1313	Human OLR1 HEK293 Cell Lysate	Inquiry
CLOE-2017	Rat Olr1 (His) HEK293 Cell Lysate	Inquiry
CLOE-2019	Rat Olr1 (Fc) HEK293 Cell Lysate	Inquiry
CLKO-0112	OLR1 KO Cell Lysate-HeLa	Inquiry
CSC-SC010841-1	Human OLR1 Stable Cell Line - HEK293	Inquiry

Cat.No.	Product Name	Price
AD11218Z	Human OLR1 adenoviral particles	Inquiry
LV20262L	human OLR1 (NM_001172633) lentivirus particles	Inquiry
LV20263L	human OLR1 (NM_002543) lentivirus particles	Inquiry
LV20264L	human OLR1 (NM_001172632) lentivirus particles	Inquiry

Cat.No.	Product Name	Price
SHH361668	shRNA set against Human OLR1 (NM_002543.3)	Inquiry
SHH361672	shRNA set against Mouse OLR1 (NM_138648.2)	Inquiry
SHH361676	shRNA set against Rat OLR1 (NM_133306.2)	Inquiry
SHR050104	shRNA set against Mouse Olr1(NM_138648.2)	Inquiry
SHR050208	shRNA set against Human OLR1(NM_002543.3)	Inquiry

Cat.No.	Product Name	Price
CDCB156861	Rat OLR1 ORF clone (NM_133306.1)	Inquiry
CDCL143747	Human OLR1 ORF clone (NM_001172633.1)	Inquiry
CDFH013097	Human OLR1 cDNA Clone(NM_001172632.1)	Inquiry
CDFH013098	Human OLR1 cDNA Clone(NM_001172633.1)	Inquiry
CDFH013100	Human OLR1 cDNA Clone(NM_002543.3)	Inquiry
CDFL009708	Mouse Olr1 cDNA Clone(NM_138648.2)	Inquiry
MiUTR1H-07058	OLR1 miRNA 3'UTR clone	Inquiry
MiUTR1M-08721	OLR1 miRNA 3'UTR clone	Inquiry
SKO0052	OLR1 Validated sgRNA vector	Inquiry
CDCB156712	Cynomolgus OLR1 ORF clone	Inquiry
CDCB180249	Rabbit OLR1 ORF clone (XM_008259641.1)	Inquiry
CDCL143745	Mouse OLR1 ORF clone (NM_001172632.1)	Inquiry
CDCR266148	Mouse Olr1 ORF Clone(NM_138648.2)	Inquiry
CDCR381013	Rat Olr1 ORF Clone(NM_133306.2)	Inquiry
CDCS409009	Human OLR1 ORF Clone (BC022295)	Inquiry

Detailed Information

OLR1, a lectin-like scavenger receptor, is highly conserved in mammals and it is capable of recognizing several ligands including the protein moiety of oxidized-LDL (ox-LDL), advanced glycation end-products, gram-positive and gram-negative bacteria and apoptotic cells. OLR1 is primarily expressed in vascular cells and vasculature-rich organs, and its activation by a wide range of stimuli indicative of dyslipidemia, inflammation and damage initiates several signaling cascades including MAPKs, other protein kinases as well as transcription factors NF-kB and AP-1.

Overexpression of OLR1 has been shown in cellular components of atherosclerotic lesions. Deletion of Olr1 in Ldlr knockout (KO) mice results in much smaller atherosclerotic lesions associated with a drastic reduction of inflammation in the aortic wall. Olr1 abrogation also attenuates angiotensin II-induced hypertension. Similarly, abrogation of Olr1 reduces the extent of ischemia/reperfusion injury.

Atherosclerosis is an inflammatory vascular disease accompanying with the occlusion of the arterial vessels. The early atherosclerotic lesions include sub-endothelial accumulations of lipid-engorged macrophages (foam cells), which are represented as ‘fatty streak’. Fatty streaks are not clinically harmful, but they can be the precursors of more advanced fibrous and plaque-type lesions characterized by the accumulation of lipid-rich necrotic debris and vascular smooth muscle cells (VSMCs). Like other scavenger receptors implicated in the atherosclerosis, the OLR1 mediated the OxLDL-induced NF-κB activation in VSMCs, which in turn augmented the ICAM-dependent monocyte adhesion onto the activated VSMCs. More striking finding is that the depletion or internalization of the OLR1 impaired the activation of PDGFRβ, a major growth factor receptor of VSMCs. This evidence suggests a novel function of OLR1 as a potential co-receptor for PDGFRβ, similar to a co-receptor neuropilin-1 for vascular endothelial growth factor receptor-2. Thus, it is likely that OLR1 is the first scavenger receptor that simultaneously coordinates the growth signaling and the inflammatory response in VSMCs (Figure 1). If this is the case, it is suspected that a PDGFR-targeted therapy against atherosclerosis and in-stent restenosis may cause a medical complication in hypercholesterolemia or hyperlipidemia patients.

Figure 1. OLR1 plays a dual receptor function in VSMCs . An association between obesity and atherosclerotic disease states in humans is well established.

Associations with obesity have been found for various cancers, including breast and prostate neoplasms, suggesting a mechanistic overlap in the pathobiology of atherogenesis and tumorigenesis. Recently, Olr1, acting through NF-kB mediated inflammatory signaling, was strongly implicated in carcinogenesis. OLR1 locates within the area of chromosome 12p, which has been identified as the AD-susceptible region, and plays a role in lipid metabolism. Therefore, it has also been suggested to be a good candidate gene for Alzheimer’s disease (AD). Several SNPs within OLR1 have been reported to have association with AD among Caucasians.

References:

Khaidakov M, et al. Oxidized LDL receptor 1 (OLR1) as a possible link between obesity, dyslipidemia and cancer. Plos One, 2011, 6(5):e20277.
Kang D H, et al. Vascular Proteomics Reveal Novel Proteins Involved in SMC Phenotypic Change: OLR1 as a SMC Receptor Regulating Proliferation and Inflammatory Response. Plos One, 2015, 10(8):e0133845.
Wang Z T, et al. Association of lectin-like oxidized low density lipoprotein receptor 1 (OLR1) polymorphisms with late-onset Alzheimer disease in Han Chinese. Ann Transl Med, 2018;6(10):172.
Changping H, et al. LOX-1 abrogation reduces myocardial ischemia–reperfusion injury in mice. Journal of Molecular & Cellular Cardiology, 2008, 44(1):76.

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