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Myh6

Official Full Name
myosin, heavy polypeptide 6, cardiac muscle, alpha
Organism
Mus musculus
GeneID
17888
Background
Enables microfilament motor activity. Involved in cardiac muscle contraction. Acts upstream of or within several processes, including adult heart development; regulation of heart contraction; and striated muscle cell development. Located in Z disc and stress fiber. Part of myosin complex. Is expressed in several structures, including brown fat; embryo mesenchyme; great vessel of heart; heart; and skeletal musculature. Used to study dilated cardiomyopathy; dilated cardiomyopathy 1EE; and hypertrophic cardiomyopathy 14. Human ortholog(s) of this gene implicated in atrial heart septal defect (multiple); heart conduction disease (multiple); and intrinsic cardiomyopathy (multiple). Orthologous to human MYH6 (myosin heavy chain 6). [provided by Alliance of Genome Resources, Feb 2025]
Synonyms
Myh6; Myhca; Myhc-a; alphaMHC; alpha-MHC; A830009F23Rik;

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