JUNDM2

Official Full Name

Jun dimerization protein 2

Organism

Homo sapiens

Gene ID

122953

Background

Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and sequence-specific double-stranded DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II. Part of RNA polymerase II transcription regulator complex. [provided by Alliance of Genome Resources, Feb 2025]

Synonyms

JDP2; JUNDM2

Cat.No.	Product Name	Price
CSC-DC007859	Panoply™ Human JDP2 Knockdown Stable Cell Line	Inquiry
CSC-SC007859	Panoply™ Human JDP2 Over-expressing Stable Cell Line	Inquiry

Cat.No.	Product Name	Price
AD08320Z	Human JDP2 adenoviral particles	Inquiry
LV15829L	human JDP2 (NM_130469) lentivirus particles	Inquiry
LV15830L	human JDP2 (NM_001135049) lentivirus particles	Inquiry

Cat.No.	Product Name	Price
SHH322031	shRNA set against Human JDP2 (NM_130469.3)	Inquiry
SHH322035	shRNA set against Mouse JDP2 (NM_030887.2)	Inquiry
SHH322039	shRNA set against Rat JDP2 (NM_053894.1)	Inquiry
SHL185846	shRNA set against Rat Jundp2(NM_053894.1)	Inquiry
SHL185858	shRNA set against Mouse Jundm2(NM_030887.2)	Inquiry
SHW004170	shRNA set against Chicken JDP2 (NM_001277887)	Inquiry
SHW006507	shRNA set against Danio rerio JDP2 (NM_001002493)	Inquiry

Cat.No.	Product Name	Price
CDCR350193	Human JDP2 ORF Clone(NM_001135048.1)	Inquiry
MiUTR1M-06192	JDP2 miRNA 3'UTR clone	Inquiry
CDFR013466	Rat Jdp2 cDNA Clone(NM_053894.1)	Inquiry
CDFH009525	Human JDP2 cDNA Clone(NM_001135048.1)	Inquiry
CDFH009524	Human JDP2 cDNA Clone(NM_001135049.1)	Inquiry
CDFH009523	Human JDP2 cDNA Clone(NM_001135047.1)	Inquiry
MiUTR1R-02746	JDP2 miRNA 3'UTR clone	Inquiry
MiUTR4H-TG11543	JDP2 miRNA 3'UTR clone	Inquiry
CDCL122517	Human Jundm2 ORF clone (NM_030887.2)	Inquiry
CDCR380653	Rat Jdp2 ORF Clone(NM_053894.1)	Inquiry
CDCL122375	Mouse JDP2 ORF clone (NM_001135049.1)	Inquiry
CDCH387510	Mouse JDP2 ORF clone(NM_001205053.1)	Inquiry
CDCH387507	Human JDP2 ORF clone(NM_130469.3)	Inquiry
CDCB193833	Rabbit JDP2 ORF clone (XM_008272030.1)	Inquiry
CDCB167982	Danio rerio JDP2 ORF Clone (NM_001002493)	Inquiry
CDCR350190	Human JDP2 ORF Clone(NM_001135047.1)	Inquiry
CDCB165645	Chicken JDP2 ORF Clone (NM_001277887)	Inquiry

Detailed Information

Recent Research

The c-Jun dimerization protein 2 (JDP2) is a member of the basic leucine zipper (bZIP) superfamily, which is part of the activator protein-1 (AP-1) family. AP-1-driven genes play crucial roles in many aspects of liver carcinogenesis, including proliferation, differentiation, and reactive oxygen species (ROS) accumulation and metabolism. Some studies have showed that JDP2 forms a homodimer or a heterodimer with other Jun members to repress the transcriptional activity of the AP-1 complex. Recent studies have suggested that JDP2 may function as a tumor suppressor through its suppressive action against the AP-1 complex, which is known to drive oncogenic signals in several human malignancies. One report showed that high expression of JDP2 was signiﬁcantly correlated with smaller tumor size and early stage Hepatocellular Carcinoma (HCC). JDP2 was associated with better survival in HCC patients. This suggests that JDP2 may serve as a tumor suppressor in HCC.

JDP2 is expressed in various kinds of cells. It was originally isolated based on its association with c-Jun3, which is a component of the transcription factor AP-1, and ATF2 (activating transcription factor 2). JDP2specifically interacts with c-Jun and ATF2. JDP2 typically suppresses transcription through binding to CRE (cAMP responsive promoter element) and TRE (trans-activator response element) DNA elements found in the promoters of numerous genes by recruitment of histone deacetylases (HDACs). DNA binding was enhanced after dimerization with c-jun, but transcription was inhibited. JDP2 inhibits transcription by multiple mechanisms. Importantly, JDP2 can act as a transcriptional activator depending on the protein binding partner, specifically with the bZIP family member CHOP10 or serve as co-activator when associates with members of the steroid hormone receptor family.

JDP2 is involved in cell differentiation processes, such as adipocytes, differentiation of skeletal muscle cells and osteoclasts. Potentiation of cell differentiation is facilitated by the ability of JDP2 to induce cell cycle withdrawal. Several studies suggest that JDP2 has a dual role in malignant transformation. On the one hand, JDP2 can counteract AP-1 transcription, and thus may interfere with the oncogenic properties of c-Jun. Indeed, JDP2 expression was found to inhibit cell transformation induced by Ras in vitro and in prostate cancer xenografts injected into SCID mice. In addition, some reports showed that JDP2 suppresses cell cycle progression by down-regulation of cyclin-A2. On the other hand, JDP2 has been identified as a candidate oncogene in a high-throughput screen based on viral insertional mutagenesis in mice. Consistently, tetracycline regulated transgenic mice expressing JDP2 in liver tissue exhibited higher mortality rate and increased number and size of tumors when compared with their wild-type counterparts in hepatocellular carcinoma mouse model. Furthermore, one report showed that JDP2 expression in the host suppresses primary tumor growth. However, it promotes metastatic spread. These metastatic effects are partially mediated by BMDCs colonizing the primary tumor site and further secreting the prometastatic chemokine, CCL5.

References:

Kalfon R, et al. c-Jun dimerization protein 2 (JDP2) deficiency promotes cardiac hypertrophy and dysfunction in response to pressure overload. International Journal of Cardiology, 2017, 249.
Barbarov Y, et al. Host JDP2 expression in the bone marrow contributes to metastatic spread. Oncotarget, 2015, 6(35):37737-37749.
Heger J, et al. JDP2 overexpression provokes cardiac dysfunction in mice. Scientific Reports, 2018,8.
Chen Y L, et al. The expression of a tumor suppressor gene JDP2 and its prognostic value in hepatocellular carcinoma (HCC) patients. Human Pathology, 2017, 63:212-216.
Jonak C R, et al. c-JUN Dimerization Protein 2 (JDP2) Is a Transcriptional Repressor of Follicle-stimulating Hormone β (FSHβ) and Is Required for Preventing Premature Reproductive Senescence in Female Mice. Journal of Biological Chemistry, 2017, 292(7):2646.

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