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Hbb

Official Full Name
Homo sapiens hemoglobin, beta DNA.
Background
The alpha (HBA) and beta (HBB) loci determine the structure of the 2 types of polypeptide chains in adult hemoglobin, Hb A. The normal adult hemoglobin tetramer consists of two alpha chains and two beta chains. Mutant beta globin causes sickle cell anemia. Absence of beta chain causes beta-zero-thalassemia. Reduced amounts of detectable beta globin causes beta-plus-thalassemia. The order of the genes in the beta-globin cluster is 5-epsilon -- gamma-G -- gamma-A -- delta -- beta--3.
Synonyms
HBB; hemoglobin, beta; hemoglobin subunit beta; beta globin; CD113t C; HBD; beta globin chain; hemoglobin beta chain; CD113t-C; beta-globin; CD113t-C, HBD, beta-globin

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