FABP7

Official Full Name

fatty acid binding protein 7

Organism

Homo sapiens

Gene ID

2173

Background

The gene encodes a small, highly conserved cytoplasmic protein that bind long-chain fatty acids and other hydrophobic ligands. The encoded protein is important in the establishment of the radial glial fiber in the developing brain. Alternative splicing and promoter usage results in multiple transcript variants encoding different isoforms. Pseudogenes of this gene are found on multiple chromosomes. [provided by RefSeq, Jan 2016]

Synonyms

MRG; BLBP; FABPB; B-FABP

Cat.No.	Product Name	Price
CSC-DC005192	Panoply™ Human FABP7 Knockdown Stable Cell Line	Inquiry
CSC-SC005192	Panoply™ Human FABP7 Over-expressing Stable Cell Line	Inquiry

Cat.No.	Product Name	Price
AD05711Z	Human FABP7 adenoviral particles	Inquiry
LV12108L	human FABP7 (NM_001446) lentivirus particles	Inquiry

Cat.No.	Product Name	Price
SHH044219	shRNA set against Mouse Fabp7(NM_021272.3)	Inquiry
SHH044237	shRNA set against Human FABP7(NM_001446.3)	Inquiry
SHH288673	shRNA set against Human FABP7 (NM_001446.3)	Inquiry
SHH288681	shRNA set against Rat FABP7 (NM_030832.2)	Inquiry
SHW005803	shRNA set against Chicken FABP7 (NM_205308)	Inquiry
SHW015031	shRNA set against Danio rerio FABP7A (NM_131605)	Inquiry

Cat.No.	Product Name	Price
CDFH006273	Human FABP7 cDNA Clone(NM_001446.3)	Inquiry
MiUTR1H-03374	FABP7 miRNA 3'UTR clone	Inquiry
MiUTR1M-04559	FABP7 miRNA 3'UTR clone	Inquiry
CDCB167278	Chicken FABP7 ORF Clone (NM_205308)	Inquiry
CDCB176506	Danio rerio FABP7A ORF Clone (NM_131605)	Inquiry
CDCB183047	Rabbit FABP7 ORF clone (XM_002714798.2)	Inquiry
CDCR062200	Mouse Fabp7 ORF clone (NM_021272.3)	Inquiry
CDCR280788	Human FABP7 ORF Clone(NM_001446.3)	Inquiry
CDCR379411	Rat Fabp7 ORF Clone(NM_030832.2)	Inquiry
CDCS410280	Human FABP7 ORF Clone (BC012299)	Inquiry

Detailed Information

FABPs are low molecular weight (14-15 kDa) proteins with high Kad tissue and cell type specificity and different ligand affinities, acts as intracellular lipid chaperones responsible for uptake, transportation, storage, and signaling transmission of long-chain fatty acids. There have been at least 11 FABPs members identified to control accessibility and distribution of fatty acids, which act as ligands to several signaling processes, by the way of reversibly binding to long chain FAs. FABP7, also known as brain typed FABP, is mainly distributed in developing brain and in the adult neural tissues, however it has also been detected in Kupffer cells in the liver, fibroblastic reticular cells in the lymph nodes in recent studies. Pivotal roles on the neuronal migration and neurogenesis have been played by the expression of FABP7 in neural stem cells.

Linkage between FABP7 and tumors

FABP7 may be a useful tumor marker for its relatedness in tumorigenesis indicated by accumulative researches on human tumor and tumor-derived cell lines. Among those themes of linkage between FABP7 and several tumor phenotypes, or expression of FABP7 and corresponding function, it is easy to sum up progression of breast cancer, apocrine carcinoma, renal cell carcinoma (RCC), malignant melanoma, adenoid cystic carcinoma (ACC) is closely related with FABP7. Several in vitro researches have confirmed critical role FABP7 played in proliferation and migration of some tumor cells. Some cellular signaling transmissions were reported to be involved in FABP7 gene highly expressed tumors, for example, there is an association of EGFR expression with glioma tissue samples from patients shown to highly express FABP7 in nucleus.

FABP7 regulates Astrocyte's responses to stimulus through expression of caveolin-1

FABP7, a protein expressed by astrocytes of developing brain, has involvement in controlling astrocyte lipid homeostasis. Ligand-dependent accumulation of Toll-like receptor 4 (TLR4) and glial cell-line-derived neurotrophic factor receptor alpha 1 into lipid raft was decreased in FABP7-knockout (KO) compared with wild-type astrocytes. The expression of caveolin-1, not cavin-1, 2, 3, caveolin-2, and flotillin-1, was decreased at protein and transcriptional levels, but this situation can be rescued by re-expression of FABP7 in FABP7-KO astrocytes. Transfection of caveolin-1 into FABP7-knockout astrocytes can significantly elevate the level of TLR4 recruitment into lipid raft atter LPS stimulation. Caveolin-1 is beneficial for caveolae formation via interacting with cavin-1, moreover, its participation in regulating biological potential of caveolae is making differences in process of cell signaling transmission, fatty acid incorporation and endocytosis. Toll-like receptor 4 (TLR4) and glial cell-line-derived neurotrophic factor (GDNF), those two pattern-recognition receptors will be recruited into lipid rafts in response to extracellular stimuli, and their downstream signaling transmission is initiated intercellularly.

Lipid raft associated transient receptor potential canonical channel is necessary for glioma chemotaxis in response to stimuli, and caveolin-1 interacted connexin 43 in lipid raft promotes the invasion of human U251 glioblastoma cells, FABP7 may provide linkages to lipid raft by regulating Caveolin-1 gene, thus modulating the biology of cancer cells.

Fig 1. Role of FABP7 in tumor cell signaling (Owada et al. 2019)

References:

Yoshiteru Kagawaa, Banlanjo A. Umaru. (2018) 'Role of FABP7 in tumor cell signaling', Advances in Biological Regulation, doi: 10.1016/j.jbior.2018.09.006.
Yoshiteru Kagawa,1 Yuki Yasumoto,1 Kazem Sharifi. (2015) 'Fatty Acid-Binding Protein 7 Regulates Function of Caveolae in Astrocytes through Expression of Caveolin-1', GLIA, doi: 10.1002/glia.22784.
Poreba, M., Rostoff, P., Siniarski, A. (2018) 'Relationship between polyunsaturated fatty acid composition in serum phospholipids, systemic low-grade inflammation, and glycemic control in patients with type 2 diabetes and atherosclerotic cardiovascular disease', Cardiovasc Diabetol, doi: 10.1186/s12933-018-0672-5.

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FABP7

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Detailed Information

Linkage between FABP7 and tumors

FABP7 regulates Astrocyte's responses to stimulus through expression of caveolin-1