F3

Official Full Name

coagulation factor III, tissue factor

Organism

Homo sapiens

GeneID

2152

Background

This gene encodes coagulation factor III which is a cell surface glycoprotein. This factor enables cells to initiate the blood coagulation cascades, and it functions as the high-affinity receptor for the coagulation factor VII. The resulting complex provides a catalytic event that is responsible for initiation of the coagulation protease cascades by specific limited proteolysis. Unlike the other cofactors of these protease cascades, which circulate as nonfunctional precursors, this factor is a potent initiator that is fully functional when expressed on cell surfaces, for example, on monocytes. There are 3 distinct domains of this factor: extracellular, transmembrane, and cytoplasmic. Platelets and monocytes have been shown to express this coagulation factor under procoagulatory and proinflammatory stimuli, and a major role in HIV-associated coagulopathy has been described. Platelet-dependent monocyte expression of coagulation factor III has been described to be associated with Coronavirus Disease 2019 (COVID-19) severity and mortality. This protein is the only one in the coagulation pathway for which a congenital deficiency has not been described. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Aug 2020]

Synonyms

TF; TFA; CD142;

Cat.No.	Product Name	Price

Cat.No.	Product Name	Price

Cat.No.	Product Name	Price

Cat.No.	Product Name	Price

Detailed Information

The Functions of F3

Coagulation factor III (F3), commonly known as tissue factor, is an important member of the human coagulation factor family. The blood coagulation cascade is initiated in the human body by binding to factor VII/VIIa. Blood coagulation is a complex cellular and molecular mechanism that maintains the integrity of blood vessels, prevents bleeding (hemostasis), and responds to damage. However, several components of the coagulation system, including coagulation factors and platelets, are also involved in other physiological and pathological processes. Factor VII (FVII) binds to F3 when endothelial cells are exposed to the bloodstream. F3 then promotes FVII activation to FVIIa (activated FVII), thereby initiating an in vitro coagulation pathway followed by activation of FX and thrombin formation.

Figure 1. Coagulation factor III in the cardiovascular system (From Circulation Journal).

Recent studies have found that F3 expression is abnormal in various diseases such as sepsis, myocardial fibrosis, atherosclerosis, tumors, acute and chronic inflammation. Besides, scientists have found that another shear transcript of F3 can induce angiogenesis through integrin connections. This suggests that F3 has other important functions in addition to procoagulant effects.

F3 and Lung Cancer

Lung cancer is a malignant tumor with the highest morbidity and mortality. According to the different biological characteristics, lung cancer can be divided into non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC), of which about 80% are NSCLC. It has been proved that the tissue factor not only participated in the coagulation state of lung cancer patients, but also related to the infiltration and metastasis of cancer cells.

At the same time, F3 is also the only cell surface receptor-type transmembrane protein expressed in coagulation system. It has been found that the tissue factor in the blood of patients with malignant tumor may come from cancer cells. Although it is unclear whether it is involved in the development of malignant tumors, it can be determined that the tissue factor is closely related to the infiltration, staging and prognosis of malignant tumors.

To sum up, the expression level of F3 in NSCLC is related to infiltration, metastasis and clinical staging, which has certain guiding significance for predicting the survival period of patients.

References:

Dong hui, et al. Expression of blood coagulation factor III in peripheral blood of patients with hypercoagulable non-small cell lung cancer and its clinical significance. Chinese Tumor Clinic, 2018, 385-389.
E. D’Alessandro, et al. Tissue factor in the heart and vasculature: More than an envelope. Thrombosis Research, 2018.

Quick Inquiry

Interested in learning more?

Contact us today for a free consultation with the scientific team and discover how Creative Biogene can be a valuable resource and partner for your organization.

Request a quote today!

Inquiry