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ERCC8

Official Full Name
ERCC excision repair 8, CSA ubiquitin ligase complex subunit
Organism
Homo sapiens
GeneID
1161
Background
This gene encodes a WD repeat protein, which interacts with Cockayne syndrome type B (CSB) protein and with p44 protein, a subunit of the RNA polymerase II transcription factor IIH. Mutations in this gene have been identified in patients with hereditary disease Cockayne syndrome (CS). CS cells are abnormally sensitive to ultraviolet radiation and are defective in the repair of transcriptionally active genes. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2014]
Synonyms
CSA; CKN1; UVSS2;

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