Transfected Stable Cell Lines
Reliable | High-Performance | Wide Rage
Precision reporter, kinase, immune receptor, biosimilar, Cas9, and knockout stable cell lines for diverse applications.
| Cat.No. | Product Name | Price |
|---|---|---|
| CSC-DC004003 | Panoply™ Human DAAM1 Knockdown Stable Cell Line | Inquiry |
| CSC-DC005088 | Panoply™ Human ESRRG Knockdown Stable Cell Line | Inquiry |
| CSC-SC004003 | Panoply™ Human DAAM1 Over-expressing Stable Cell Line | Inquiry |
| CSC-SC005088 | Panoply™ Human ESRRG Over-expressing Stable Cell Line | Inquiry |
| Cat.No. | Product Name | Price |
|---|---|---|
| AD04562Z | Human DAAM1 adenoviral particles | Inquiry |
| AD05616Z | Human ESRRG adenoviral particles | Inquiry |
| LV10259L | human DAAM1 (NM_014992) lentivirus particles | Inquiry |
| LV11957L | human ESRRG (NM_001438) lentivirus particles | Inquiry |
| LV11958L | human ESRRG (NM_001134285) lentivirus particles | Inquiry |
| Cat.No. | Product Name | Price |
|---|---|---|
| SHH274293 | shRNA set against Human DAAM1 (NM_014992.2) | Inquiry |
| SHH274301 | shRNA set against Rat DAAM1 (NM_001108030.1) | Inquiry |
| SHG220463 | shRNA set against Mouse Daam1(NM_172464.2) | Inquiry |
| SHG220517 | shRNA set against Mouse Daam1(NM_026102.2) | Inquiry |
| SHH274297 | shRNA set against Mouse DAAM1 (NM_172464.2) | Inquiry |
| SHH287473 | shRNA set against Human ESRRG (NM_001438.3) | Inquiry |
| SHH287477 | shRNA set against Mouse ESRRG (NM_011935.3) | Inquiry |
| SHH287481 | shRNA set against Rat ESRRG (NM_203336.2) | Inquiry |
| SHW000674 | shRNA set against Chicken ESRRG (NM_001007081) | Inquiry |
| SHW003064 | shRNA set against Chicken DAAM1 (NM_001193624) | Inquiry |
| Cat.No. | Product Name | Price |
|---|---|---|
| CDCB162149 | Chicken ESRRG ORF Clone (NM_001007081) | Inquiry |
| MiUTR1M-03669 | DAAM1 miRNA 3'UTR clone | Inquiry |
| MiUTR1M-03668 | DAAM1 miRNA 3'UTR clone | Inquiry |
| CDFR007701 | Rat Daam1 cDNA Clone(NM_001108030.1) | Inquiry |
| MiUTR3H-08618 | DAAM1 miRNA 3'UTR clone | Inquiry |
| MiUTR4H-TG11148 | ESRRG miRNA 3'UTR clone | Inquiry |
| CDCR061492 | Human ESRRG ORF clone (NM_001243507.1) | Inquiry |
| CDCR061494 | Human ESRRG ORF clone (NM_001243506.1) | Inquiry |
| CDCR061496 | Human ESRRG ORF clone (NM_001243505.1) | Inquiry |
| CDCR061500 | Mouse Esrrg ORF clone (NM_001243792.1) | Inquiry |
| CDCG000573 | Mouse ESRRG ORF clone(NM_011935.3) | Inquiry |
| CDCR327570 | Human ESRRG ORF Clone(NM_206595.2) | Inquiry |
| CDCR349882 | Human ESRRG ORF Clone(NM_001134285.2) | Inquiry |
| CDCR374728 | Rat Daam1 ORF Clone(NM_001108030.1) | Inquiry |
| CDCR382388 | Rat Esrrg ORF Clone(NM_203336.2) | Inquiry |
| CDCS407990 | Human ESRRG ORF Clone (BC064700) | Inquiry |
| CDCB193351 | Rabbit DAAM1 ORF clone (XM_002709767.2) | Inquiry |
| CDCB184585 | Rabbit ESRRG ORF clone (XM_008268422.1) | Inquiry |
| CDCB164539 | Chicken DAAM1 ORF Clone (NM_001193624) | Inquiry |
| CDCR061490 | Human ESRRG ORF clone (NM_001243518.1) | Inquiry |
| CDCR258150 | Mouse Daam1 ORF Clone(NM_026102.2) | Inquiry |
Dishevelled Associated Activator of Morphogenesis 1 (DAAM1) is a pivotal adapter protein, belonging to the Dishevelled-associated activator of morphogenesis (DAAM) family. Much like its counterparts in the Grb7/Gr10/Grb14 protein family, DAAM1 interacts with various receptor tyrosine kinases, exerting profound influence over diverse signaling pathways within the cell.
Initially identified in multiple tissues, DAAM1 mRNA expression was found to be abundant in skeletal muscle, brain, heart, cartilage, and adipose tissue in mice. Similarly, in humans, DAAM1 exhibited higher expression in the pancreas and skeletal muscle, intermediate levels in the brain and cardiac muscle, and lower expression in tissues such as the liver, kidney, lung, placenta, spleen, prostate, ovary, colon, testis, and small intestine.
The protein structure of DAAM1 includes various domains such as the pleckstrin homology domain (PH), the N-terminal proline-rich region (PR), a Ras-associating domain (RA), a C-terminal Src homology 2 domain (SH2), and the family-specific BPS domain. These domains are pivotal in defining DAAM1's functions. For example, the SH2 domain allows DAAM1 to interact with phosphorylated tyrosine residues of other proteins, facilitating its role in various signaling pathways. Additionally, the BPS domain has been implicated in DAAM1's involvement in insulin signaling, where it interacts with insulin receptor (IR) and insulin-like growth factor 1 receptor (IGF1R), modulating essential cellular responses. DAAM1, like other methylated proteins, directs the nucleation and elongation of new actin filaments using its conserved methylated homology-2 (FH2) structural domain. It is a Rho-regulated protein that has been linked to the regulation of neuronal development and formation of the stomach. It has been identified as a binding protein for the Wnt receptor-associated protein Disheveled.
The multifaceted role of DAAM1 in cellular processes, encompasses cell proliferation, metabolism, and apoptosis. Notably, dysregulation of DAAM1 expression has been linked to specific disease contexts, including certain types of cancers. For instance, upregulation of DAAM1 mRNA has been detected in primary cervical squamous cell cancers. Experimental depletion of DAAM1 mRNA through siRNA techniques resulted in marked inhibition of cell growth in cervical squamous cell carcinoma, underscoring DAAM1's significance as a survival factor in this disease.
Figure 1. DAAM1 participates in the Wnt/PCR Pathway.
DAAM1 is a versatile adapter protein crucial in regulating diverse cellular processes and exhibits significant relevance in the context of cancer, specifically cervical squamous cell carcinoma. Its intricate regulatory mechanisms, coupled with its interactions in critical signaling pathways, highlight its importance in both normal cellular functions and disease contexts.
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