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COX11


Official Full Name
cytochrome c oxidase copper chaperone COX11
Organism
Homo sapiens
Gene ID
1353
Background
Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes a protein which is not a structural subunit, but may be a heme A biosynthetic enzyme involved in COX formation, according to the yeast mutant studies. However, the studies in Rhodobacter sphaeroides suggest that this gene is not required for heme A biosynthesis, but required for stable formation of the Cu(B) and magnesium centers of COX. This human protein is predicted to contain a transmembrane domain localized in the mitochondrial inner membrane. Multiple transcript variants encoding different isoforms have been found for this gene. A related pseudogene has been found on chromosome 6. [provided by RefSeq, Jun 2009]
Synonyms
COX11P; MC4DN23

Cat.No. Product Name Price
SHG193915 shRNA set against Mouse Cox11(NM_199008.2) Inquiry
SHH268165 shRNA set against Mouse COX11 (NM_199008.2) Inquiry
SHH268169 shRNA set against Rat COX11 (NM_001109575.1) Inquiry
SHW011201 shRNA set against Danio rerio COX11 (NM_001082958) Inquiry
Cat.No. Product Name Price
CDCR049820 Human COX11 ORF clone (NM_001162861.1) Inquiry
CDFH004112 Human COX11 cDNA Clone(NM_001162861.1) Inquiry
CDFH004113 Human COX11 cDNA Clone(NM_001162862.1) Inquiry
CDFR009108 Rat Cox11 cDNA Clone(NM_001109575.1) Inquiry
MiUTR1M-03256 COX11 miRNA 3'UTR clone Inquiry
MiUTR3H-06154 COX11 miRNA 3'UTR clone Inquiry
MiUTR3H-06155 COX11 miRNA 3'UTR clone Inquiry
MiUTR3H-06156 COX11 miRNA 3'UTR clone Inquiry
CDCB172676 Danio rerio COX11 ORF Clone (NM_001082958) Inquiry
CDCR049822 Human COX11 ORF clone (NM_001162862.1) Inquiry
CDCR049824 Mouse Cox11 ORF clone (NM_199008.2) Inquiry
CDCR376195 Rat Cox11 ORF Clone(NM_001109575.1) Inquiry
CDCS408712 Human COX11 ORF Clone (BC005895) Inquiry
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