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Akr1B3

Official Full Name
aldo-keto reductase family 1 member B
Organism
Mus musculus
GeneID
11677
Background
Enables L-glucuronate reductase activity and aldose reductase (NADPH) activity. Involved in L-ascorbic acid biosynthetic process and fructose biosynthetic process. Acts upstream of or within several processes, including metanephric collecting duct development; regulation of urine volume; and renal water homeostasis. Is active in cytosol. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in arteriosclerosis; cataract; diabetic neuropathy; diabetic retinopathy; and type 2 diabetes mellitus. Orthologous to human AKR1B1 (aldo-keto reductase family 1 member B). [provided by Alliance of Genome Resources, Feb 2025]
Synonyms
Akr1b1; AR; ALR2; Ahr1; Ahr-1; Aldr1; Akr1b3; Aldor1;

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