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ACER1


Official Full Name
alkaline ceramidase 1
Organism
Homo sapiens
Gene ID
125981
Background
Ceramides are synthesized during epidermal differentiation and accumulate within the interstices of the stratum corneum, where they represent critical components of the epidermal permeability barrier. Excess cellular ceramide can trigger antimitogenic signals and induce apoptosis, and the ceramide metabolites sphingosine and sphingosine-1-phosphate (S1P) are important bioregulatory molecules. Ceramide hydrolysis in the nucleated cell layers regulates keratinocyte proliferation and apoptosis in response to external stress. Ceramide hydrolysis also occurs at the stratum corneum, releasing free sphingoid base that functions as an endogenous antimicrobial agent. ACER1 is highly expressed in epidermis and catalyzes the hydrolysis of very long chain ceramides to generate sphingosine (Houben et al., 2006 [PubMed 16477081]; Sun et al., 2008 [PubMed 17713573]).[supplied by OMIM, Jul 2010]
Synonyms
MJDL

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AD00538Z Human ACER1 adenoviral particles Inquiry
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SHH230238 shRNA set against Rat ACER1 (NM_001106875.1) Inquiry
SHH230230 shRNA set against Human ACER1 (NM_133492.2) Inquiry
SHH230234 shRNA set against Mouse ACER1 (NM_175731.4) Inquiry
SHW008262 shRNA set against Danio rerio ACER1 (NM_001017603) Inquiry
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CDFR006602 Rat Acer1 cDNA Clone(NM_001106875.1) Inquiry
MiUTR4H-TG10472 ACER1 miRNA 3'UTR clone Inquiry
CDCB169737 Danio rerio ACER1 ORF Clone (NM_001017603) Inquiry
CDCB183378 Rabbit ACER1 ORF clone (XM_008252874.1) Inquiry
CDCH014734 Human ACER1 ORF clone(NM_133492.2) Inquiry
CDCR273279 Mouse Acer1 ORF Clone(NM_175731.4) Inquiry
CDCR373653 Rat Acer1 ORF Clone(NM_001106875.1) Inquiry
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