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Human TLR4 Stable Cell Line-HEK293

Cat.No.
CSC-RO0056
Description
This cell line is a stably transfected cell line which expresses human Toll-like receptor 4 (TLR4) with an N-terminal HA tag.
Host Cell
HEK293
Shipping
Dry ice
Source
HEK293
Species
Human
Subgroup
Human
Background
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor has been implicated in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria. Mutations in this gene have been associated with differences in LPS responsiveness.
Gene Information
Gene Symbol
TLR4
Synonyms
TOLL; CD284; TLR-4; ARMD10
Gene ID
UniProt ID
O00206
Chromosome Location
9q33.1

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