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Tlr4 Knockout Mouse Bone Marrow Neutrophils

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Cat.No.
CSC-RK0075
Background
Toll-like receptor 4 is a protein that in humans is encoded by the TLR4 gene. TLR4 is a toll-like receptor. It detects lipopolysaccharide on Gram-negative bacteria and is thus important in the activation of the innate immune system. TLR4 has also been designated as CD284 (cluster of differentiation 284). The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor is most abundantly expressed in placenta, and in myelomonocytic subpopulation of the leukocytes. It has been implicated in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria. Mutations in this gene have been associated with differences in LPS responsiveness. Also, several transcript variants of this gene have been found, but the protein coding potential of most of them is uncertain.
Growth Properties
Suspension
Host Cell
Bone marrow neutrophils
Ship
Dry ice
Gene Information
Official Symbol
Tlr4
Synonyms
TLR4; toll-like receptor 4; lipopolysaccharide response; Lps; Ly87; Ran/M1; Rasl2-8;
Gene ID
Pathway
Amoebiasis, organism-specific biosystem; Amoebiasis, conserved biosystem; Chagas disease (American trypanosomiasis), organism-specific biosystem; Chagas disease (American trypanosomiasis), conserved biosystem; Influenza A, organism-specific biosystem; Influenza A, conserved biosystem; Legionellosis, organism-specific biosystem;
Function
lipopolysaccharide binding; lipopolysaccharide receptor activity; phosphatidylinositol 3-kinase binding; protein binding; receptor activity; transmembrane signaling receptor activity;

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