Cynomolgus TLR4 ORF clone

Name: Cynomolgus TLR4 ORF clone
SKU: CDCB156616
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CDCB156616

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Product Information

Gene Information

Cat. No.	CDCB156616
Description	ORF Clone of Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) toll-like receptor 4 DNA. Identical with XM_005591542.1 [ Macaca mulatta (Rhesus monkey) ]:2097 G/C not causing the amino acid variation.
Product Type	ORF clone
Gene Abbr	TLR4
Species	Cynomolgus
ORF Size	2481 bp
Sequence	ATGACGTCTG CCTTGCGCCT GGCTGGGACT CTGATCCCAG CCATGGCCTT CCTCTCCTGC GTGAGACCAG AAAGCTGGGA GCCCTGCGTG GAGGTGGTTC CTAACATTAC TTATCAATGC ATGGAGCTGA AGTTCTACAA AATCCCCGAC AACATCCCCT TCTCAACCAA GAACCTGGAC CTGAGCTTTA ATCCCCTGAG GCATTTAGGC AGCTATAGCT TCCTCCGTTT TCCAGAACTG CAGGTGCTGG ATTTATCCAG GTGTGAAATC CAGACAATTG AAGATGGGGC ATATCAGAGC CTAAGCCACC TCTCCACTTT AATATTGACA GGAAACCCCA TCCAGAGTTT AGCCCTGGGA GCCTTTTCTG GACTATCAAG TTTACAGAAG CTGGTGGCTG TGGAGACAAA TCTAGCATCT CTAGAGAACT TCCCCATTGG ACATCTCAAA ACTTTGAAAG AACTTAATGT GGCTCACAAT CTTATCCAGT CTTTCAAATT ACCTGAGTAT TTTTCTAATC TGACCAATCT AGAGCACTTG GACCTTTCCA GTAACAAGAT TCAAAATATT TATTGCAAAG ACTTGCAGGT TCTACATCAA ATGCCCCTAT CCAATCTCTC TTTAGACCTG TCCCTGAACC CTATAAACTT TATCCAACCA GGTGCATTTA AAGAAATTAG GCTTCATAAG CTGACTTTGA GAAGTAATTT TGATGATTTA AATGTAATGA AAACTTGTAT TCAAGGTCTG GCTGGTTTAG AAGTCCATCG TTTGGTTCTG GGAGAATTTA GAAATGAAAG AAACTTGGAA GAGTTTGACA AATCTTCTCT GGAGGGATTG TGCAATTTGA CCATTGAAGA ATTCCGATTA ACATACTTAG ACTACTACCT CGATAATATT ATTGACTTAT TTAATTGTTT GGCAAATGTT TCTTCATTTT CCCTGGTGAG TGTGAGTATT AAAAGGGTAG AAGACTTTTC TTATAATTTC AGATGGCAAC ATTTAGAATT AGTTAACTGT AAATTTGAAC AGTTTCCCAC ATTGGAACTC GAATCTCTCA AAAGGCTTAC TTTCACTGCC AACAAAGGTG GGAATGCTTT TTCAGAAGTT GATCTACCAA GCCTTGAGTT TCTAGATCTC AGTAGAAATG GCTTGAGTTT CAAAGGTTGC TGTTCTCAAA GTGATTTTGG GACAACCAGC CTAAAGTATT TAGATCTGAG CTTCAATGAT GTTATTACCA TGAGTTCAAA CTTCTTGGGC TTAGAAAAAC TAGAACATCT GGATTTCCAG CATTCCAATT TGAAACAGAT GAGTCAATTT TCAGTATTCC TATCACTCAG AAACCTCATT TACCTTGACA TTTCTCATAC TCACACCAGA GTTGCTTTCA ATGGCATCTT CGATGGCTTG CTCAGTCTCA AAGTCTTAAA AATGGCTGGC AATTCTTTCC AGGAAAACTT CCTTCCAGAT ATCTTCACAG ATCTGAAAAA CTTGACCTTC CTGGACCTCT CTCAGTGTCA ATTGGAGCAG TTGTCTCCAA CAGCATTTGA CACACTCAAC AAGCTTCAGG TACTAAATAT GAGCCACAAC AACTTCTTTT CATTGGATAC GTTTCCTTAT AAGTGTCTGC CCTCCCTCCA GGTTCTCGAT TACAGTCTCA ATCACATAAT GACTTCCAAC AACCAGGAAC TACAGCATTT TCCAAGTAGT CTAGCTTTCT TAAATCTTAC TCAGAATGAC TTTGCTTGTA CTTGTGAACA CCAGAGTTTC CTGCAGTGGA TCAAGGACCA GAGGCAGCTC TTGGTGGAAG CTGAACGAAT GGAATGTGCA ACACCTTCAG ATAAACAGGG CATGCCGGTG CTGAGTTTGA ATATTACCTG TCAGATGAAT AAGACCATCA TTGGTGTGTC TGTGTTCAGT GTGCTTGTGG TATCTGTTGT AGCAGTTCTG GTCTATAAGT TCTATTTTCA CCTGATGCTT CTTGCTGGCT GCATAAAGTA TGGTAGAGGT GAAAACATCT ATGATGCCTT TGTTATCTAC TCAAGCCAGG ATGAGGACTG GGTAAGGAAT GAACTAGTAA AGAATTTAGA AGAAGGCGTG CCTCCCTTTC AGCTCTGCCT TCACTACAGA GACTTTATTC CCGGTGTGGC CATTGCTGCA AACATCATCC ATGAAGGTTT CCATAAAAGC CGAAAGGTGA TTGTTGTGGT GTCCCAGCAC TTCATCCAGA GCCGCTGGTG TATCTTTGAA TATGAGATTG CTCAGACCTG GCAGTTTCTG AGCAGTCGTG CAGGCATAAT CTTCATTGTC CTGCAGAAGG TGGAGAAGAC CCTGCTCAGG CAGCAGGTGG AGCTGTACCG CCTTCTCAGC AGGAACACTT ACCTGGAGTG GGAGGACAGT GTCCTGGGGC AGCACATCTT CTGGAGACGA CTCAGAAAAG CCCTGTTGGA TGGCAGATCG TGGAATCCAG AAGAACAGTA G

Target Gene

TLR4

Background

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. In silico studies have found a particularly strong binding of surface TLR4 with the spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of Coronavirus disease-2019 (COVID-19). This receptor has also been implicated in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria. Mutations in this gene have been associated with differences in LPS responsiveness, and with susceptibility to age-related macular degeneration. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2020]

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