Tel: 1-631-626-9181 (USA)   44-207-097-1828 (Europe)
  Email:

Human BRCA2 Knockdown Cell Line-HeLa

Cat.No.
CSC-RK0027
Abbr
HeLa-HuBRCA2 Knockdown
Alias
BRCA2,FACD,GLM3,FANCB,FANCD,PNCA2,
Growth Properties
Adherent
Host Cell
HeLa
Morphology
Epithelial
Shipping
Dry ice
Species
Human
Background
Inherited mutations in BRCA1 and this gene, BRCA2, confer increased lifetime risk of developing breast or ovarian cancer. Both BRCA1 and BRCA2 are involved in maintenance of genome stability, specifically the homologous recombination pathway for double-strand DNA repair. The BRCA2 protein contains several copies of a 70 aa motif called the BRC motif, and these motifs mediate binding to the RAD51 recombinase which functions in DNA repair. BRCA2 is considered a tumor suppressor gene, as tumors with BRCA2 mutations generally exhibit loss of heterozygosity (LOH) of the wild-type allele.

Quick Inquiry

   Please input "biogene" as verification code.