Human KCNA5 Stable Cell Line-CHO-K1

Name: Human KCNA5 Stable Cell Line-CHO-K1
SKU: CSC-RI0030
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CSC-RI0030

Host Cell : CHO-K1 Size : >1x10⁶ frozen cells/vial

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Cell Line Information

Cell Culture Information

Safety and Packaging

Gene Information

Cat. No.	CSC-RI0030
Description	This cell line is engineered to overexpress human KCNA5.
Target Gene	KCNA5
Gene Species	Homo sapiens (Human)
Abbr	CHO-HuKCNA5
Alias	KCNA5, HK2, HPCN1, Kv1.5, HCK1, PCN1, ATFB7, KV1.5, MGC117058, MGC117059
Host Cell	CHO-K1
Host Cell Species	Cricetulus griseus (Chinese hamster)
Applications	1. Gene expression studies 2. Signaling pathway research 3. Drug screening and toxicology 4. Channelopathies research
Size	>1x10⁶ frozen cells/vial
Stability	Validated for at least 10 passages
Quality Control	Negative for bacteria, yeast, fungi and mycoplasma.
Storage	Liquid nitrogen
Shipping	Dry ice

Revival	Rapidly thaw cells in a 37°C water bath. Transfer contents into a tube containing pre-warmed media. Centrifuge cells and seed into a 25 cm2 flask containing pre-warmed media.
Growth Properties	Adherent
Morphology	Epithelial-like

Mycoplasma	Negative
Format	One frozen vial containing millions of cells
Storage	Liquid nitrogen
Safety Considerations	The following safety precautions should be observed. 1. Use pipette aids to prevent ingestion and keep aerosols down to a minimum. 2. No eating, drinking or smoking while handling the stable line. 3. Wash hands after handling the stable line and before leaving the lab. 4. Decontaminate work surface with disinfectant or 70% ethanol before and after working with stable cells. 5. All waste should be considered hazardous. 6. Dispose of all liquid waste after each experiment and treat with bleach.
Ship	Dry ice

Gene Name	KCNA5 potassium voltage-gated channel, shaker-related subfamily, member 5 [ Homo sapiens ]
Gene Symbol	KCNA5
Synonyms	KCNA5; potassium voltage-gated channel, shaker-related subfamily, member 5; potassium voltage-gated channel subfamily A member 5; HK2; HPCN1; Kv1.5; potassium channel 1; cardiac potassium channel; potassium channel protein; voltage-gated potassium channel HK2; insulinoma and islet potassium channel; voltage-gated potassium channel protein Kv1.5; voltage-gated potassium channel subunit Kv1.5; HCK1; PCN1; ATFB7; KV1.5; MGC117058; MGC117059;
GeneID	3741
Uni ProtID	P22460
mRNA Refseq	BC099665
Chromosome Location	12p13
Function	delayed rectifier potassium channel activity; outward rectifier potassium channel activity; potassium channel inhibitor activity; receptor binding; voltage-gated ion channel activity;
Pathway	Neuronal System, organism-specific biosystem; Potassium Channels, organism-specific biosystem; Voltage gated Potassium channels, organism-specific biosystem;
MIM	176267

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Background

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Customer Reviews

Kv1.5 is expressed in the brain (hippocampus, pituitary, microglia, oligodendrocytes and Schwann cells) as well as kidney, colon, aorta, pulmonary artery and smooth muscle. This ion channel is involved in the maintenance of the resting membrane potential and therefore regulates the activity electrically excitable cells. Kv1.5 is potentially a target for the management of atrial fibrillation. Since they are not found in the ventricles, drugs selective for this channel may be beneficial in the treatment of atrial fibrillation without the risk of causing ventricular arrhythmias. Apart from these instances where the purpose is to develop a cardiovascular drug targeted to Kv1.5, an interaction of lead development compounds with this channel is best avoided. This is due to the fact that the channel has such a widespread distribution and controls membrane excitability.

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