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Human KCNA5 Stable Cell Line-CHO

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Cat.No.
CSC-RI0030
Background
Kv1.5 is expressed in the brain (hippocampus, pituitary, microglia, oligodendrocytes and Schwann cells) as well as kidney, colon, aorta, pulmonary artery and smooth muscle. This ion channel is involved in the maintenance of the resting membrane potential and therefore regulates the activity electrically excitable cells. Kv1.5 is potentially a target for the management of atrial fibrillation. Since they are not found in the ventricles, drugs selective for this channel may be beneficial in the treatment of atrial fibrillation without the risk of causing ventricular arrhythmias. Apart from these instances where the purpose is to develop a cardiovascular drug targeted to Kv1.5, an interaction of lead development compounds with this channel is best avoided. This is due to the fact that the channel has such a widespread distribution and controls membrane excitability.
Growth Properties
Adherent
Morphology
Epithelial-like
Host Cell
CHO-K1
Ship
Dry ice
Gene Information
Official Symbol
KCNA5
Synonyms
KCNA5; potassium voltage-gated channel, shaker-related subfamily, member 5; potassium voltage-gated channel subfamily A member 5; HK2; HPCN1; Kv1.5; potassium channel 1; cardiac potassium channel; potassium channel protein; voltage-gated potassium channel HK2; insulinoma and islet potassium channel; voltage-gated potassium channel protein Kv1.5; voltage-gated potassium channel subunit Kv1.5; HCK1; PCN1; ATFB7; KV1.5; MGC117058; MGC117059;
Gene ID
MIM
UniProt ID
P22460
Chromosome Location
12p13
Pathway
Neuronal System, organism-specific biosystem; Potassium Channels, organism-specific biosystem; Voltage gated Potassium channels, organism-specific biosystem;
Function
delayed rectifier potassium channel activity; outward rectifier potassium channel activity; potassium channel inhibitor activity; receptor binding; voltage-gated ion channel activity;

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