Human KCNA5 Stable Cell Line-CHO

Name: Human KCNA5 Stable Cell Line-CHO
SKU: CSC-RI0030

Cat.No. : CSC-RI0030 Host Cell: CHO-K1

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Cell Line Information

Cell Culture Information

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Cat. No.	CSC-RI0030
Description	This cell line is engineered to overexpress human KCNA5.
Gene	KCNA5
Gene Species	Homo sapiens (Human)
Alias	KCNA5, HK2, HPCN1, Kv1.5, HCK1, PCN1, ATFB7, KV1.5, MGC117058, MGC117059
Host Cell	CHO-K1
Host Cell Species	Cricetulus griseus (Chinese hamster)
Morphology	Epithelial-like
Stability	Validated for at least 10 passages
Application	1. Gene expression studies 2. Signaling pathway research 3. Drug screening and toxicology 4. Channelopathies research
Quality Control	Negative for bacteria, yeast, fungi and mycoplasma.
Shipping	Dry ice
Storage	Liquid nitrogen

Revival	Rapidly thaw cells in a 37°C water bath. Transfer contents into a tube containing pre-warmed media. Centrifuge cells and seed into a 25 cm² flask containing pre-warmed media.
Growth Properties	Adherent

Mycoplasma	Negative
Format	One frozen vial containing millions of cells
Storage	Liquid nitrogen
Safety Considerations	The following safety precautions should be observed. 1. Use pipette aids to prevent ingestion and keep aerosols down to a minimum. 2. No eating, drinking or smoking while handling the stable line. 3. Wash hands after handling the stable line and before leaving the lab. 4. Decontaminate work surface with disinfectant or 70% ethanol before and after working with stable cells. 5. All waste should be considered hazardous. 6. Dispose of all liquid waste after each experiment and treat with bleach.
Ship	Dry ice

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Kv1.5 is expressed in the brain (hippocampus, pituitary, microglia, oligodendrocytes and Schwann cells) as well as kidney, colon, aorta, pulmonary artery and smooth muscle. This ion channel is involved in the maintenance of the resting membrane potential and therefore regulates the activity electrically excitable cells. Kv1.5 is potentially a target for the management of atrial fibrillation. Since they are not found in the ventricles, drugs selective for this channel may be beneficial in the treatment of atrial fibrillation without the risk of causing ventricular arrhythmias. Apart from these instances where the purpose is to develop a cardiovascular drug targeted to Kv1.5, an interaction of lead development compounds with this channel is best avoided. This is due to the fact that the channel has such a widespread distribution and controls membrane excitability.

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