Human KCNA1 Stable Cell Line-CHO-K1

Name: Human KCNA1 Stable Cell Line-CHO-K1
SKU: CSC-RI0026
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CSC-RI0026

Host Cell : CHO-K1 Size : >1x10⁶ frozen cells/vial

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Cell Line Information

Cell Culture Information

Safety and Packaging

Gene Information

Cat. No.	CSC-RI0026
Description	This cell line is engineered to overexpress human KCNA1.
Background	Kv1.1 is a voltage-gated, delayed rectifier, potassium channel. It is expressed in the brain, heart, retina, skeletal muscle and pancreatic islets and is primarily involved with maintaining the resting membrane potential and modulating electrical excitability in neurons and muscle cells. Mutations of this ion channel have been linked to episodic ataxia, an autosomal dominant human disorder that produces persistent myokymia (successive, involuntary, small muscle contractions or tics that affect a bundle of muscles).
Target Gene	KCNA1
Gene Species	Homo sapiens (Human)
Abbr	CHO-HuKCNA1
Alias	KCNA1, AEMK, HUK1, Kv1.1, MBK1, RBK1, EA1, MK1, HBK1, KV1.1, MGC126782, MGC138385
Host Cell	CHO-K1
Host Cell Species	Cricetulus griseus (Chinese hamster)
Applications	1. Gene expression studies 2. Signaling pathway research 3. Drug screening and toxicology 4. Channelopathies research
Size	>1x10⁶ frozen cells/vial
Stability	Validated for at least 10 passages
Quality Control	Negative for bacteria, yeast, fungi and mycoplasma.
Storage	Liquid nitrogen
Shipping	Dry ice

Revival	Rapidly thaw cells in a 37°C water bath. Transfer contents into a tube containing pre-warmed media. Centrifuge cells and seed into a 25 cm2 flask containing pre-warmed media.
Growth Properties	Adherent
Morphology	Epithelial-like

Mycoplasma	Negative
Format	One frozen vial containing millions of cells
Storage	Liquid nitrogen
Safety Considerations	The following safety precautions should be observed. 1. Use pipette aids to prevent ingestion and keep aerosols down to a minimum. 2. No eating, drinking or smoking while handling the stable line. 3. Wash hands after handling the stable line and before leaving the lab. 4. Decontaminate work surface with disinfectant or 70% ethanol before and after working with stable cells. 5. All waste should be considered hazardous. 6. Dispose of all liquid waste after each experiment and treat with bleach.
Ship	Dry ice

Gene Name	KCNA1 potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia) [ Homo sapiens ]
Gene Symbol	KCNA1
Synonyms	EA1; MK1; AEMK; HBK1; HUK1; MBK1; RBK1; KV1.1
Gene Description	potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia)
GeneID	3736
Uni ProtID	Q09470
mRNA Refseq	NM_000217.2
Protein Refseq	NP_000208.2
Chromosome Location	12p13.32
Function	delayed rectifier potassium channel activity; potassium channel activity; potassium ion transmembrane transporter activity;
Pathway	Neuronal System, organism-specific biosystem; Potassium Channels, organism-specific biosystem; Voltage gated Potassium channels, organism-specific biosystem;
MIM	176260

Quick Inquiry

Q & A

Customer Reviews

Customer Q&As

What is the method of establishment for the Human KCNA1 Stable Cell Line-CHO?

A: The cell line was established by stably transfecting the human KCNA1 gene (potassium channel subfamily A member 1) into CHO (Chinese hamster ovary) cells.

What are the specific uses of this cell line in neurobiology research?

A: It is mainly used to study the role of KCNA1 in the regulation of neuronal excitability and neural signal transduction.

What are the advantages of using the Human KCNA1 Stable Cell Line-CHO in drug discovery and screening?

A: It is suitable for screening drugs that affect the function of the KCNA1 channel, especially for research on treatments for neurodegenerative diseases and epilepsy.

What are the potential uses of the Human KCNA1 Stable Cell Line-CHO in cardiology research?

A: It can be used to study the role of KCNA1 in cardiac cells, especially in the mechanisms of cardiac arrhythmias.

What types of disease model studies are the Human KCNA1 Stable Cell Line-CHO important for?

A: It has significant value in studies of disease models for neurological disorders such as epilepsy, motor neuron diseases, and cardiac arrhythmias.

How can genetic stability be ensured during long-term culture of the Human KCNA1 Stable Cell Line-CHO?

A: By regularly performing genotypic and phenotypic testing to ensure the consistency of KCNA1 expression and stability of cell characteristics.

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