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Rat Oprd1 Stable Cell Line-CHO dhfr-

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Cat.No.
CSC-RG0340
Background
Delta opioid receptor (DOR) inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. In rats, morphine tolerance is associated with DOR-mediated activation of cortical CCKergic systems. There are indications that some DOR antagonists produce potent antitussive effects and may be considered as candidates of antitussive drugs. In contrast, some DOR agonists have shown antinociceptive, seizuregenic and convulsive properties, implicating a role for the receptor in depression. Clinical experiments have demonstrated that exogenously administered delta opioid peptides had antidepressant activity, suggesting that the receptor may provide a new therapeutic target for treating depression.
Growth Properties
Adherent
Morphology
Epithelial-like
Host Cell
CHO dhfr-
Ship
Dry ice
Gene Information
Official Symbol
Oprd1
Synonyms
OPRD1; opioid receptor, delta 1; delta-type opioid receptor; DOR-1; D-OR-1; opioid receptor A;
Gene ID
Pathway
Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; G alpha (i) signalling events, organism-specific biosystem; GPCR downstream signaling, organism-specific biosystem; GPCR ligand binding, organism-specific biosystem; GPCRs, Class A Rhodopsin-like, organism-specific biosystem; Neuroactive ligand-receptor interaction, organism-specific biosystem; Neuroactive ligand-receptor interaction, conserved biosystem;
Function
G-protein coupled receptor activity; enkephalin receptor activity; opioid receptor activity; receptor activity; signal transducer activity;

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