The TRPV3 channel belongs to the transient receptor potential channel (TRP) super-family that consists of 7 subfamilies. The channels exist as tetramers where each subunit consists of 6 putative trans-membrane domains. In this respect they have a similar topology to many other voltage-gated channels. The vast majority are permeable to both monovalent cations and calcium. The TRPV3 channel was first cloned in 2002 by two groups based on its homology to known TRPV channels. It shares 40-50% homology to TRPV1 and is activated at temperatures ≥ 34 °C as well as by 2-Aminoethoxydiphenyl borate and monoterpenes such as camphor. In humans it is expressed in skin keratinocytes, trigeminal ganglia, spinal cord and brain. It is also located in DRG neurons where it may even form heteromultimers with TRPV1. The specific distribution of this channel, coupled with its thermal sensitivity and potential activation by a variety of inflammatory mediators, have suggested that it may represent a novel drug target for the treatment of inflammatory pain.