There is now compelling evidence to suggest that TRPA1 is primarily responsible for mediating sensations of noxious cold (<17 deg) and has a significant role in conveying inflammatory pain responses. TRPA1 is located in a subset of DRG neurons that respond to noxious cold and in recombinant expression systems noxious cold has been shown to directly activate this channel. Furthermore, the same set of sensory neurons in DRG and neurons in the trigeminal ganglia produce nociceptive responses to irritant agents such allyl isothiocyanate (AITC) from mustard oil, allicin from garlic and cinnamaldehyde from cinnamon that have all been shown to selectively activate TRPA1. TRPA1 deficient mice do not show pain behaviour associated with administration of AITC or noxious cold, clearly demonstrating that these behaviours are mediated by TRPA1.
TRPA1; transient receptor potential cation channel, subfamily A, member 1; ANKTM1, ankyrin like with transmembrane domains 1; transient receptor potential cation channel subfamily A member 1; transformation-sensitive protein p120; ankyrin-like with transmembrane domains 1; ankyrin-like with transmembrane domains protein 1; ANKTM1;