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Human PTGS2 Knockdown Cell Line-HeLa

Cat.No.
CSC-RK0264
Abbr
HeLa-HuPTGS2 Knockdown
Alias
PTGS2,COX2,PHS II,COX-2,PHS-2,PGG/HS,PGHS-2,hCox-2,GRIPGHS,
Growth Properties
Adherent
Host Cell
HeLa
Morphology
Epithelial
Shipping
Dry ice
Species
Human
Background
Prostaglandin endoperoxide H synthase, COX 2, converts arachidonic acid (AA) to prostaglandin endoperoxide H2. PGHSs are targets for NSAIDs and COX-2 specific inhibitors called coxibs. PGHS-2 is a sequence homodimer. Each monomer of the enzyme has a peroxidase and a COX active site. The COX enzymes catalyze the conversion of arachidonic acid to prostaglandins in a two steps. First, hydrogen is abstracted from carbon 13 of arachidonic acid, and then two molecules of oxygen are added by the COX-2, giving PGG2. Second, PGG2 is reduced to PGH2 in the peroxidase active site. The synthesized PGH2 is converted to prostaglandins (PGD2, PGE2, PGF2α), prostacyclin (PGI2), or thromboxane A2 by tissue-specific isomerases. Both the peroxidase and the cyclooxygenase activities are inactivated during catalysis by mechanism-based, first-order processes, which means that PGHS-2 peroxidase or cyclooxygenase activities fall to zero within 1–2 minutes, even in the presence of sufficient substrates.

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