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Human KCNH3 Stable Cell Line-HEK293

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Cat.No.
CSC-RI0034
Background
The human KCNH3 gene encodes for the pore-forming subunit of the subfamily H (eag-related) voltage-gated potassium channel #3, a protein known as the Kv12.2 potassium ion channel. The gene was cloned & first described as BEC1 by Miyake et al. 1999. Gene deletion experiments in mice showed KCNH3 knock-out mice performed better in working memory, reference memory, and attention-related behavioral assays than their wild-type littermates; enhanced performance was also observed in heterozygous mutants. Interestingly, when KCNH3 was overexpressed in the forebrain impaired performance was observed in the behavioral assays. Altering KCNH3 expression changed hippocampal neuronal excitability and synaptic plasticity; suggesting that Kv12.2 could be an interesting target for cognitive enhancement or perhaps epilepsy.
Growth Properties
Adherent
Morphology
Epithelial
Host Cell
HEK293
Ship
Dry ice
Gene Information
Official Symbol
KCNH3
Synonyms
KCNH3; potassium voltage-gated channel, subfamily H (eag-related), member 3; potassium voltage-gated channel subfamily H member 3; BEC1; elk2; Kv12.2; ELK channel 2; brain-specific eag-like channel 1; ether-a-go-go-like potassium channel 2; ether-a-go-go K(+) channel family member; voltage-gated potassium channel subunit Kv12.2; ELK2; KIAA1282;
Gene ID
MIM
UniProt ID
Q9ULD8
Chromosome Location
12q13
Pathway
Neuronal System, organism-specific biosystem; Potassium Channels, organism-specific biosystem; Voltage gated Potassium channels, organism-specific biosystem;
Function
two-component sensor activity; voltage-gated ion channel activity; voltage-gated potassium channel activity;

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