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Human GRPR Stable Cell Line-CHO

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Cat.No.
CSC-RG0803
Background
Bombesin is a 14 amino acid peptide isolated from frog skin. The mammalian counterparts are neuromedin B (NMB) and gastrin-releasing peptide (GRP). Three bombesin receptor subtypes (BB1, BB2 and BB3) have been classified in humans according to the rank order of potency to the endogenous ligands: NMB, GPR and bombesin. BB1 binds to NMB with 10-800-fold higher affinity than GRP and is also named NMB receptor, whereas BB2 binds to GRP with 50-300-fold higher affinity than NMB and therefore named GRP receptor. BB2 receptors are widely distributed in the CNS as well as in the gastrointestinal tract and reproductive organs. In CNS, Bombesin-like peptides induce satiety and play a role in thermoregulation and induce histamine-independent pruritus. These peptides also act via the BB2 receptor to regulate sleep disorders, depression and involved in the regulation of emotionally motivated learning, memory and food intake. In the gastrointestinal tract, GRPR receptors are involved in smooth muscle contractility, pancreatic secretion and the release of many other gastrointestinal peptides.
Growth Properties
Adherent
Morphology
Epithelial-like
Host Cell
CHO-K1
Stability
12 passages of continuous culture (6 weeks) at 2 passages/week
Ship
Dry ice
Gene Information
Official Symbol
GRPR
Synonyms
GRPR; gastrin-releasing peptide receptor; GRP-R; GRP-preferring bombesin receptor;
Gene ID
MIM
UniProt ID
P30550
Chromosome Location
Xp22.2
Pathway
Calcium signaling pathway, organism-specific biosystem; Calcium signaling pathway, conserved biosystem; Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; G alpha (q) signalling events, organism-specific biosystem; GPCR downstream signaling, organism-specific biosystem; GPCR ligand binding, organism-specific biosystem; GPCRs, Class A Rhodopsin-like, organism-specific biosystem;
Function
G-protein coupled peptide receptor activity; bombesin receptor activity; neuropeptide binding; receptor activity; signal transducer activity;

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