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Human ERCC1 Knockdown Cell Line-HeLa

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Cat.No.
CSC-RK0002
Background
The mammalian ERCC1 (Excision Repair Cross Complementing) polypeptide is required for nucleotide excision repair (NER) of damaged DNA and is homologous to Saccharomyces cerevisiae RAD10, which functions in repair and mitotic intrachromosomal recombination. NER mechanism involves dual incisions on both sides of the damage catalyzed by two nucleases. In mammalian cells XPG cleaves 3" of the DNA lesion while the ERCC1-XPF complex makes the 5" incision. Elevated levels of ERCC1 have also been reported in Cisplatin-resistant cells.
Growth Properties
Adherent
Morphology
Epithelial
Host Cell
HeLa
Ship
Dry ice
Gene Information
Official Symbol
ERCC1
Synonyms
ERCC1; excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence); DNA excision repair protein ERCC-1; RAD10; UV20; COFS4;
Gene ID
MIM
UniProt ID
P07992
Chromosome Location
19q13.32
Pathway
DNA Repair, organism-specific biosystem; Dual incision reaction in GG-NER, organism-specific biosystem; Dual incision reaction in TC-NER, organism-specific biosystem; Fanconi anemia pathway, organism-specific biosystem; Fanconi anemia pathway, conserved biosystem; Formation of incision complex in GG-NER, organism-specific biosystem; Formation of transcription-coupled NER (TC-NER) repair complex, organism-specific biosystem;
Function
damaged DNA binding; damaged DNA binding; endonuclease activity; hydrolase activity; protein C-terminus binding; protein binding; protein domain specific binding; single-stranded DNA binding; contributes_to single-stranded DNA specific endodeoxyribonuclease activity; contributes_to structure-specific DNA binding;

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