Tel: 1-631-626-9181 (USA)   44-207-097-1828 (Europe)
  Email:

Human ERCC1 Knockdown Cell Line-HeLa

Cat.No.
CSC-RK0002
Abbr
HeLa-HuERCC1 Knockdown
Alias
ERCC1,RAD10,UV20,COFS4,
Growth Properties
Adherent
Host Cell
HeLa
Morphology
Epithelial
Shipping
Dry ice
Species
Human
Background
The mammalian ERCC1 (Excision Repair Cross Complementing) polypeptide is required for nucleotide excision repair (NER) of damaged DNA and is homologous to Saccharomyces cerevisiae RAD10, which functions in repair and mitotic intrachromosomal recombination. NER mechanism involves dual incisions on both sides of the damage catalyzed by two nucleases. In mammalian cells XPG cleaves 3" of the DNA lesion while the ERCC1-XPF complex makes the 5" incision. Elevated levels of ERCC1 have also been reported in Cisplatin-resistant cells.

Quick Inquiry

   Please input "biogene" as verification code.