Recombinant Mouse C5 (Tag free)

Name: Recombinant Mouse C5 (Tag free)
SKU: RP00187

Cat.No. : RP00187 Tag: Tag free

Expressed Region: Asn679-Arg755 Expression System: E.coli

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Product Details

Target Information

Cat. No.	RP00187
Description	The Recombinant Mouse C5 is produced in our E.coli expression system. The amino acid region expressed is Asn679-Arg755 without tag.
Species	Mouse
Tag	Tag free
Mol. Weight	9 KDa
Expressed Region	Asn679-Arg755
Expression System	E.coli
Format	Powder
Formulation	Lyophilized from a 0.2 μm filtered solution of 20mM PB, 350mM NaCl, pH 7.5.
Conjugate	Unconjugated
Endotoxin Level	< 1 EU/µg of protein by LAL method
Purity	>95% as determined by SDS-PAGE. >90% as determined by SEC-MALS.
Shipping	The product is shipped with ice packs. Upon receipt, store it immediately at the temperature recommended below.
Storage	Upon receipt, this product is stable for up to 6 months at temperatures below -70°C. Once reconstituted, the product is stable for up to 1 week at 4°C and up to 3 months at -20°C. Please avoid repeated freeze-thaw cycles.
Reconstitution	Always centrifuge tubes before opening. It is recommended to reconstitute the solution to a concentration above 100 μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

Target Gene	C5
Background	This gene encodes a component of the complement system, a part of the innate immune system that plays an important role in inflammation, host homeostasis, and host defense against pathogens. The encoded preproprotein is proteolytically processed to generate multiple protein products, including the C5 alpha chain, C5 beta chain, C5a anaphylatoxin and C5b. The C5 protein is comprised of the C5 alpha and beta chains, which are linked by a disulfide bridge. Cleavage of the alpha chain by a convertase enzyme results in the formation of the C5a anaphylatoxin, which possesses potent spasmogenic and chemotactic activity, and the C5b macromolecular cleavage product, a subunit of the membrane attack complex (MAC). Mutations in this gene cause complement component 5 deficiency, a disease characterized by recurrent bacterial infections. Alternative splicing results in multiple transcript variants.
Synonyms	Complement C5; Hemolytic Complement; C5; Hc

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