Human SLAMF7 Stable Cell Line - HEK293T

Name: Human SLAMF7 Stable Cell Line - HEK293T
SKU: CSC-RO0569
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CSC-RO0569

Host Cell : HEK293T Size : >1x10⁶ frozen cells/vial

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Cell Line Information

Cell Culture Information

Safety and Packaging

Gene Information

Cat. No.	CSC-RO0569
Description	This cell line is derived from HEK293T and is engineered to stably overexpress Human SLAMF7.
Target Gene	SLAMF7
Gene Species	Homo sapiens (Human)
Host Cell	HEK293T
Host Cell Species	Homo sapiens (Human)
Applications	1. Studying the interactions between immune cells and cancer cells 2. Studying the mechanisms of resistance to immune checkpoint blockade 3. High-throughput screening 4. Drug target validation
Size	>1x10⁶ frozen cells/vial
Stability	Validated for at least 10 passages
Quality Control	Negative for bacteria, yeast, fungi and mycoplasma.
Storage	Liquid nitrogen
Shipping	Dry ice

Revival	Rapidly thaw cells in a 37°C water bath. Transfer contents into a tube containing pre-warmed media. Centrifuge cells and seed into a 25 cm2 flask containing pre-warmed media.
Growth Properties	Cells are cultured as a monolayer at 37°C in a humidified atmosphere with 5% CO₂. Split at 80-90% confluence, approximately 1:3-1:6.

Mycoplasma	Negative
Format	One frozen vial containing millions of cells
Storage	Liquid nitrogen
Safety Considerations	The following safety precautions should be observed. 1. Use pipette aids to prevent ingestion and keep aerosols down to a minimum. 2. No eating, drinking or smoking while handling the stable line. 3. Wash hands after handling the stable line and before leaving the lab. 4. Decontaminate work surface with disinfectant or 70% ethanol before and after working with stable cells. 5. All waste should be considered hazardous. 6. Dispose of all liquid waste after each experiment and treat with bleach.
Ship	Dry ice

Gene Name	SLAMF7 SLAM family member 7 [ Homo sapiens ]
Gene Symbol	SLAMF7
Synonyms	19A; CS1; CD319; CRACC
Gene Description	SLAM family member 7
Gene ID	57823
Uni Prot ID	Q9NQ25
m RNA Refseq	NM_021181.3
Protein Refseq	NP_067004.3
Chromosome Location	1q23.1-q24.1
Function	receptor activity;
MIM	606625

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Q & A

Customer Reviews

Customer Q&As

What are the unique advantages of the Human SLAMF7 Stable Cell Line - HEK293T in immunology research?

A: The unique advantages of the Human SLAMF7 Stable Cell Line - HEK293T in immunology research include its stable expression of SLAMF7 (Signaling Lymphocyte Activation Molecule Family 7), which facilitates the study of SLAMF7's role in immune cell activation, proliferation, and differentiation. Additionally, the HEK293T cell line, known for its high transfection efficiency and good protein expression capabilities, makes it an ideal platform for studying SLAMF7 signaling pathways and related immune responses. This cell line can also be used for high-throughput screening studies to identify small molecules or biologics that modulate SLAMF7 function.

What are the key factors researchers need to consider when developing targeted drugs for the Human SLAMF7 Stable Cell Line - HEK293T cell line?

A: When developing targeted drugs for the Human SLAMF7 Stable Cell Line - HEK293T cell line, researchers need to consider key factors such as the expression level of SLAMF7 on the cell surface, the signaling mechanisms of SLAMF7, and the impact of drugs on cell function. Additionally, the cytotoxicity, selectivity, and pharmacological properties at the cellular level of the drugs need to be evaluated. Researchers should also consider the stability, bioavailability, and pharmacokinetics of the drugs, as well as potential off-target effects and side effects.

What is the potential application of the Human SLAMF7 Stable Cell Line - HEK293T cell line in vaccine development?

A: The potential application of the Human SLAMF7 Stable Cell Line - HEK293T cell line in vaccine development is very broad. Since SLAMF7 plays a key role in immune cell activation, this cell line can be used to study how vaccines enhance immune responses through the SLAMF7 pathway. Furthermore, by screening vaccine candidates that can activate SLAMF7 in this cell line, the vaccine development process can be accelerated. This cell line can also be used to evaluate the safety and efficacy of vaccines, especially in simulating human immune responses.

What are the common challenges and solutions when using the Human SLAMF7 Stable Cell Line - HEK293T cell line for gene editing?

A: The common challenges when using the Human SLAMF7 Stable Cell Line - HEK293T cell line for gene editing include improving gene editing efficiency, ensuring specificity of editing, and maintaining the stability of the cell phenotype after editing. Solutions may include optimizing the design of the CRISPR/Cas9 system, using more efficient transfection methods, and developing new gene editing tools such as base editors. Additionally, a rigorous screening and validation process can ensure the reliability of the edited cell line in subsequent research.

What role does the Human SLAMF7 Stable Cell Line - HEK293T cell line play in studying SLAMF7-mediated cell-to-cell interactions?

A: The Human SLAMF7 Stable Cell Line - HEK293T cell line plays a crucial role in studying SLAMF7-mediated cell-to-cell interactions. This cell line provides a stable platform for investigating how SLAMF7 affects interactions between immune cells, including their adhesion, activation, and signal transduction. Researchers can explore the function of SLAMF7 in the immune cell network and how it participates in regulating immune responses using this cell line.

How can the Human SLAMF7 Stable Cell Line - HEK293T cell line be used to study the role of SLAMF7 in immune cell development?

A: The Human SLAMF7 Stable Cell Line - HEK293T cell line can be used to study the role of SLAMF7 in immune cell development by simulating the differentiation and maturation processes of immune cells. By modulating the expression levels of SLAMF7, researchers can observe changes in the immune cell phenotype and function.

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