Panoply™ Human MALT1 Knockdown Stable Cell Line

Name: Panoply™ Human MALT1 Knockdown Stable Cell Line
SKU: CSC-DC009124
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CSC-DC009124

Host Cell : HEK293 (Hela and other cell types are also available) Validation : Real-Time RCR

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Cell Line Information

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Gene Information

Cat. No.	CSC-DC009124
Description	Creative Biogene's Knockdown Cell Lines are target specific shRNA lentivirus transduced cells. The percent knockdown levels range from 75-99% depending on the gene, as evaluated by Real-Time RCR. Cells are rigorously qualified and mycoplasma free.
Target Gene	MALT1
Host Cell	HEK293 (Hela and other cell types are also available)
Host Cell Species	Homo sapiens (Human)
Applications	(1) Studying gene functions (2) Studying gene interactions and signaling pathways (3) Target validation and drug discovery (4) Designing diseases models
Size	>1 × 10⁶ cells / vial
Stability	Validated for at least 10 passages
Validation	Real-Time RCR
Quality Control	Negative for bacteria, yeast, fungi and mycoplasma.
Storage	Liquid Nitrogen
Shipping	Dry Ice

Mycoplasma	Negative
Format	One frozen vial containing millions of cells
Storage	Liquid nitrogen
Safety Considerations	The following safety precautions should be observed. 1. Use pipette aids to prevent ingestion and keep aerosols down to a minimum. 2. No eating, drinking or smoking while handling the stable line. 3. Wash hands after handling the stable line and before leaving the lab. 4. Decontaminate work surface with disinfectant or 70% ethanol before and after working with stable cells. 5. All waste should be considered hazardous. 6. Dispose of all liquid waste after each experiment and treat with bleach.
Ship	Dry ice

Gene Name	MALT1 mucosa associated lymphoid tissue lymphoma translocation gene 1 [ Homo sapiens ]
Gene Symbol	MALT1
Synonyms	MLT; MLT1
Gene Description	mucosa associated lymphoid tissue lymphoma translocation gene 1
GeneID	10892
Uni ProtID	Q9UDY8
mRNA Refseq	NM_173844.1
Protein Refseq	NP_776216.1
Chromosome Location	18q21
Function	cysteine-type endopeptidase activity; contributes_to kinase activator activity; peptidase activity; protease binding; protein binding; protein self-association; signal transducer activity; ubiquitin-protein ligase activity;
Pathway	Activation of NF-kappaB in B Cells, organism-specific biosystem; Adaptive Immune System, organism-specific biosystem; B cell receptor signaling pathway, organism-specific biosystem; B cell receptor signaling pathway, conserved biosystem; BCR signaling pathway, organism-specific biosystem; Canonical NF-kappaB pathway, organism-specific biosystem; Downstream Signaling Events Of B Cell Receptor (BCR), organism-specific biosystem;
MIM	604860

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Mucosa-associated lymphoma antigen 1 (MALT1) is an oncogene in diffuse large B-cell lymphoma (DLBCL) and mucosa-associated lymphoid tissue (MALT) lymphoma subsets. However, the role of MALT1 in various cancers, particularly prostate cancer, remains poorly understood. This study demonstrates that MALT1 overexpression is significantly associated with mismatch repair (MMR) gene mutation levels and significantly promotes prostate cancer cell proliferation and clonogenicity both in vivo and in vitro, while reducing apoptosis. MALT1 expression is closely associated with immune checkpoint genes, tumor mutational burden (TMB), and microsatellite instability (MSI) in most cancers. Gene ontology (GO) analysis reveals that co-expressed MALT1 genes are involved in heterocellular adhesion, actin filament-mediated motility regulation, and action potential regulation. Gene set enrichment analysis (GSEA) revealed that MALT1 expression is associated with multiple signaling pathways in prostate cancer, including the NF-κB signaling pathway, the Wnt/β-catenin signaling pathway, and the TGF-β signaling pathway. Furthermore, MALT1 expression was significantly associated with the infiltration of immune cells (including B cells, CD8+ T cells, dendritic cells, and macrophages), but negatively correlated with the infiltration of CD4+ cells in prostate cancer. Therefore, MALT1 may be an emerging therapeutic target for various cancers, especially prostate cancer.

Researchers used Matrigel-coated Transwell chambers to assess tumor invasiveness. Cells that degraded Matrigel and crossed the membrane were counted, and the results showed that the number of invasive PC-3 cells in the MALT1 knockdown cell group was lower than that in the control group. Similar results were obtained for LNCaP cells (Figure 1A). To assess whether downregulation of MALT1 expression affected the metastatic ability of PC-3 and LNCaP cells, they performed Transwell experiments. The results showed that the migration ability of MALT1 knockdown cells was significantly reduced (Figure 1B).

Figure 1. Downregulation of MALT1 inhibited the migration and invasion of PCa cells. (Tan H, et al., 2021)

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