Panoply™ Human AOC3 Over-expressing Stable Cell Line

Name: Panoply™ Human AOC3 Over-expressing Stable Cell Line
SKU: CSC-SC000708
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CSC-SC000708

Host Cell : HEK293 (CHO and other cell types are also available) Size : >1x10⁶ frozen cells/vial

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Cell Line Information

Cell Culture Information

Safety and Packaging

Gene Information

Cat. No.	CSC-SC000708
Description	Using Creative Biogene's proprietary lentiviral vectors, we subclone the target gene into lentivector, generate the lentivirus particles, sequentially infect the cell line HEK293 (other cell types are also available according to your requirements), and select the clones constantly expressing target gene at high level.
Target Gene	AOC3
Gene Species	Homo sapiens (Human)
Host Cell	HEK293 (CHO and other cell types are also available)
Host Cell Species	Species varies
Applications	1. Gene expression studies 2. Signaling pathway research 3. Drug screening and toxicology 4. Disease research
Size	2 × 10^6 cells / vial
Stability	Validated for at least 10 passages
Quality Control	Negative for bacteria, yeast, fungi and mycoplasma.
Storage	Liquid nitrogen
Shipping	Dry Ice

Revival

Rapidly thaw cells in a 37°C water bath. Transfer contents into a tube containing pre-warmed media. Centrifuge cells and seed into a 25 cm2 flask containing pre-warmed media.

Mycoplasma	Negative
Format	One frozen vial containing millions of cells
Storage	Liquid nitrogen
Safety Considerations	The following safety precautions should be observed. 1. Use pipette aids to prevent ingestion and keep aerosols down to a minimum. 2. No eating, drinking or smoking while handling the stable line. 3. Wash hands after handling the stable line and before leaving the lab. 4. Decontaminate work surface with disinfectant or 70% ethanol before and after working with stable cells. 5. All waste should be considered hazardous. 6. Dispose of all liquid waste after each experiment and treat with bleach.
Ship	Dry ice

Gene Name	AOC3 amine oxidase, copper containing 3 (vascular adhesion protein 1) [ Homo sapiens ]
Gene Symbol	AOC3
Synonyms	HPAO; SSAO; VAP1; VAP-1
Gene Description	amine oxidase, copper containing 3 (vascular adhesion protein 1)
Gene ID	8639
Uni Prot ID	Q16853
m RNA Refseq	NM_003734.2
Protein Refseq	NP_003725.1
Chromosome Location	17q21
Function	aliphatic-amine oxidase activity; aminoacetone:oxygen oxidoreductase(deaminating) activity; calcium ion binding; cation channel activity; copper ion binding; copper ion binding; phenethylamine:oxygen oxidoreductase (deaminating) activity; primary amine oxidase activity; protein homodimerization activity; quinone binding; tryptamine:oxygen oxidoreductase (deaminating) activity;
Pathway	Glycine, serine and threonine metabolism, organism-specific biosystem; Glycine, serine and threonine metabolism, conserved biosystem; Phenylalanine metabolism, organism-specific biosystem; Phenylalanine metabolism, conserved biosystem; Tyrosine metabolism, organism-specific biosystem; Tyrosine metabolism, conserved biosystem; beta-Alanine metabolism, organism-specific biosystem;
MIM	603735

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Amine oxidase copper containing 3 (AOC3) has been reported to play a crucial regulatory role in biological pathways, the immune microenvironment, and cellular function. However, the potential function of AOC3 in cancer remains largely unexplored. Here, researchers comprehensively analyzed the potential function of AOC3 in pan-cancer using multiple online databases and analytical methods, including mutation and differential expression analysis, pathway analysis, and immunoassay. Subsequently, they assessed the function of AOC3 in colorectal cancer (CRC) cells. Pan-cancer analysis revealed that the mutation frequency of AOC3 was highest in patients with embryonal tumors. AOC3 expression was significantly downregulated in most cancers, and differential expression of AOC3 was primarily concentrated in CRC and female tumors. Enrichment analysis indicated that AOC3 is involved in the PPAR signaling pathway. Furthermore, bioinformatics analysis revealed the association between AOC3 and immune cell infiltration in the tumor microenvironment. Cellular experiments confirmed that AOC3 can significantly regulate apoptosis and cell cycle progression in CRC cells. In summary, these studies not only comprehensively analyzed the potential mechanisms of AOC3 in pan-cancer, but also verified the potential regulatory role of AOC3 through CRC cell experiments.

Here, the HTC116 cell apoptosis experiment showed that, compared with control cells, the apoptosis rate of AOC3-overexpressing HTC116 cells was significantly increased (Figure 1A-B).

Figure 1. Comparison of apoptosis rate between two groups (HCT116 + NC group and HTC116 + AOC3-OE group). (Wang G, et al., 2025)

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