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Mouse IL-8 LUCPorter stable cell lines-RAW

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Cat.No.
CSC-RR0016
Background
Interleukin-8 (IL-8) is a chemokine produced by macrophages and other cell types such as epithelial cells. It is also synthesized by endothelial cells, which store IL-8 in their storage vesicles, the Weibel-Palade bodies. In humans, the interleukin-8 protein is encoded by the IL8 gene. There are many receptors of the surface membrane capable to bind IL-8; the most frequently studied types are the G protein-coupled serpentine receptors CXCR1, and CXCR2. Expression and affinity to IL-8 is different in the two receptors (CXCR1 >CXCR2). Toll-like receptors are the receptors of the innate immune system. These receptors recognize antigen patterns (like LPS in gram negative bacteria). Through a chain of biochemical reactions, IL-8 is secreted and is an important mediator of the immune reaction in the innate immune system response.
Growth Properties
Adherent
Morphology
Macrophage
Host Cell
RAW
Ship
Dry ice
Gene Information
Official Symbol
Cxcr2
Synonyms
CXCR2; chemokine (C-X-C motif) receptor 2; C-X-C chemokine receptor type 2; CXC-R2; CXCR-2; IL-8R B; GRO/MGSA receptor; IL-8 receptor alpha chain; chemokine (C-X-C) receptor 2; interleukin 8 receptor, beta; interleukin-8 receptor type B; high affinity interleukin-8 receptor B; CD128; IL8RA; Il8rb; CDw128; Cmkar2; Gpcr16; IL-8Rh; IL-8rb; mIL-8RH;
Gene ID
Pathway
Chemokine receptors bind chemokines, organism-specific biosystem; Chemokine signaling pathway, organism-specific biosystem; Chemokine signaling pathway, conserved biosystem; Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; Endocytosis, organism-specific biosystem;
Function
C-X-C chemokine receptor activity; G-protein coupled receptor activity; chemokine receptor activity; chemokine receptor activity; interleukin-8 binding; interleukin-8 receptor activity; interleukin-8 receptor activity; protein binding; receptor activity; signal transducer activity;

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