MAPK14 Knockout Cell Line-293T

Mitogen-activated protein kinase 14, commonly referred to as MAPK14 or p38 α, is an important member of the MAP kinase family and plays a crucial role in cellular signaling. MAPK14/p38 α is encoded by the MAPK14 gene located on chromosome 6 in humans. Upon activation by the upstream kinases MKK3, MKK4, or MKK6, MAPK14 phosphorylates a range of substrates, including transcription factors, enzymes, and other protein kinases. This phosphorylation process converts external signals into appropriate cellular responses, ranging from differentiation, apoptosis, and autophagy to inflammation and cell cycle regulation. Due to the important role MAPK14 plays in these processes, it has become a focus of research in various diseases and conditions, especially inflammatory diseases, cancer, and neurodegenerative diseases. One of the best-known functions of MAPK14 is its involvement in inflammatory responses. It regulates the production of proinflammatory cytokines such as IL-1, TNF-alpha, and IL-6, and also affects the activity of COX-2, an enzyme that is essential for prostaglandin synthesis. As a result, MAPK14 has become a target for anti-inflammatory drug development, and researchers are exploring p38 MAPK inhibitors as potential therapeutics for arthritis, Crohn's disease, and other inflammatory diseases.