This gene is one of the PMS2 gene family members found in clusters on chromosome 7. The product of this gene is involved in DNA mismatch repair. It forms a heterodimer with MLH1 and this complex interacts with other complexes bound to mismatched bases. Mutations in this gene are associated with hereditary nonpolyposis colorectal cancer, Turcot syndrome, and are a cause of supratentorial primitive neuroectodermal tumors. Alternatively spliced transcript variants have been observed for this gene.
ATP binding; ATPase activity; DNA binding; contributes_to MutSalpha complex binding; endonuclease activity; hydrolase activity; mismatched DNA binding; protein binding; single base insertion or deletion binding; contributes_to single-stranded DNA binding;