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Human PMS2 Knockdown Cell Line-LN428 Glioma

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Cat.No.
CSC-RK0232
Background
This gene is one of the PMS2 gene family members found in clusters on chromosome 7. The product of this gene is involved in DNA mismatch repair. It forms a heterodimer with MLH1 and this complex interacts with other complexes bound to mismatched bases. Mutations in this gene are associated with hereditary nonpolyposis colorectal cancer, Turcot syndrome, and are a cause of supratentorial primitive neuroectodermal tumors. Alternatively spliced transcript variants have been observed for this gene.
Growth Properties
Adherent
Morphology
Epithelial
Host Cell
LN428 glioma
Ship
Dry ice
Gene Information
Official Symbol
PMS2
Synonyms
PMS2; PMS2 postmeiotic segregation increased 2 (S. cerevisiae); PMSL2, postmeiotic segregation increased (S. cerevisiae) 2; mismatch repair endonuclease PMS2; H_DJ0042M02.9; HNPCC4; PMS1 protein homolog 2; DNA mismatch repair protein PMS2; PMSL2; PMS2CL;
Gene ID
MIM
UniProt ID
P54278
Chromosome Location
7p22.1
Pathway
BRCA1-associated genome surveillance complex (BASC), organism-specific biosystem; Direct p53 effectors, organism-specific biosystem; Fanconi anemia pathway, organism-specific biosystem; Fanconi anemia pathway, conserved biosystem; Mismatch repair, organism-specific biosystem; Mismatch repair, conserved biosystem;
Function
ATP binding; ATPase activity; DNA binding; contributes_to MutSalpha complex binding; endonuclease activity; hydrolase activity; mismatched DNA binding; protein binding; single base insertion or deletion binding; contributes_to single-stranded DNA binding;

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