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Human NFAT Prom/Luciferase/Hyg Reporter Stable Cell Line-HeLa

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Cat.No.
CSC-RR0032
Background
Transcription factors of the NFAT (nuclear factor of activated T cells) family are expressed in most immune system cells and in a range of other cell types. NFAT plays the immunomodulatory role, primarily in T-cell activation and differentiation. In addition, NFAT target genes are involved in the regulation of apoptosis and differentiation in nonimmune cell types. A key aspect of the regulated transcription response to immune stimuli is the Ca2+/calmodulin-dependent signal cascade which leads to the activation of the NFAT and induction of its target genes. This NFAT signaling pathway is the target of the immunosuppressive drugs cyclosporin A and FK506, which act at the level of calcineurin activation. The pathway can be interfered by a number of viruses, including human immunodeficiency virus, hepatitis C virus, and African swine fever virus (ASFV).
Growth Properties
Adherent
Morphology
Epithelial
Host Cell
HeLa
Stability
Cells will undergo genotypic changes resulting in reduced responsiveness over time in normal cell-culture conditions. Genetic instability is a biological phenomenon that occurs in all stably transfected cells. Therefore, it is critical to prepare an adequate number of frozen stocks at early passages.
Ship
Dry ice
Gene Information
Official Symbol
NFATC4
Synonyms
NFATC4; nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4; nuclear factor of activated T-cells, cytoplasmic 4; NFAT3; NF-AT3; T cell transcription factor NFAT3; T-cell transcription factor NFAT3; NF-ATc4;
Gene ID
MIM
UniProt ID
Q14934
Chromosome Location
14q11.2
Pathway
Axon guidance, organism-specific biosystem; Axon guidance, conserved biosystem; B cell receptor signaling pathway, organism-specific biosystem; B cell receptor signaling pathway, conserved biosystem; ErbB2/ErbB3 signaling events, organism-specific biosystem; HTLV-I infection, organism-specific biosystem; HTLV-I infection, conserved biosystem;
Function
DNA binding; sequence-specific DNA binding transcription factor activity; transcription coactivator activity;

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