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Human HIF Prom/Luciferase/Hyg Reporter Stable Cell Line-NIH3T3

Cat.No.
CSC-RR0029
Abbr
NIH3T3-HuHIF Prom/Luciferase/Hyg
Growth Properties
Adherent
Host Cell
NIH3T3
Morphology
Fibroblast
Shipping
Dry ice
Species
Human
Stability
Cells will undergo genotypic changes resulting in reduced responsiveness over time in normal cell culture conditions. Genetic instability is a biological phenomenon that occurs in all stably transfected cells. Therefore, it is critical to prepare an adequate number of frozen stocks at early passages.
Background
Hypoxia inducible factor (HIF) is a heterodimeric transcription factor composed of two basic helix-loop-helix proteins-HIF-1a and HIF-1beta (or Arnt). The HIF a/beta dimmer binds to hypoxia-response element and activates the transcription of many genes that code for proteins that are involved in angiogenesis, glucose metabolism, cell proliferation/survival and invasion/metastasis, such as VEGF, FLT-1, EPO, and Leptin. Studies have shown the association of aberrant HIF activities with human diseases such as cancer and heart disease. HIF-1a is overexpressed in human cancers as a result of intratumoral hypoxia as well as genetic alterations, such as gain-of-function mutations in oncogenes (for example, ERBB2) and loss-of-function mutations in tumour-suppressor genes (for example, VHL and PTEN).

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